Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.
Canault M, Ghalloussi D, Grosdidier C, et al.
The Journal of Experimental Medicine, 211(7), 1349-1362 (2014)
Junichi Takino et al.
Cell adhesion & migration, 7(3), 262-266 (2013-04-09)
Ras guanyl nucleotide releasing proteins (RasGRPs) are guanine nucleotide exchange factors that activate Ras and Rap. We recently reported that xrasgrp2, which is a homolog of the human rasgrp2, plays a role in vasculogenesis and/or angiogenesis during early development of...
S Toki et al.
The Journal of comparative neurology, 437(4), 398-407 (2001-08-15)
CalDAG-GEFI and CalDAG-GEFII (identical to RasGRP) are novel, brain-enriched guanine nucleotide exchange factors (GEFs) that can be stimulated by calcium and diacylglycerol and that can activate small GTPases, including Ras and Rap1, molecules increasingly recognized as having signaling functions in...
Kentaro Nagamine et al.
Biological & pharmaceutical bulletin, 33(7), 1138-1142 (2010-07-08)
Ras guanyl nucleotide-releasing protein 2 (RASGRP2) is a calcium- and diacylglycerol-responsive guanine nucleotide exchange factor. Previously, we reported that XRASGRP2, a homolog of human RASGRP2, is expressed in the vascular region of the Xenopus embryo during embryogenesis. Here, we report...
Sandra Andersson et al.
PloS one, 9(12), e115911-e115911 (2014-12-30)
The sequencing of the human genome has opened doors for global gene expression profiling, and the immense amount of data will lay an important ground for future studies of normal and diseased tissues. The Human Protein Atlas project aims to...