Sadanori Watanabe et al.
Journal of cell science, 126(Pt 8), 1773-1784 (2013-02-28)
Cytokinesis is initiated by constriction of the cleavage furrow, and completed with separation of the two daughter cells by abscission. Control of transition from constriction to abscission is therefore crucial for cytokinesis. However, the underlying mechanism is largely unknown. Here...
Evidence of association between bipolar disorder and Citron on chromosome 12q24.
A Lyons-Warren et al.
Molecular psychiatry, 10(9), 807-809 (2005-06-29)
Murielle P Serres et al.
The Journal of clinical investigation, 122(3), 844-858 (2012-02-02)
p27(Kip1) (p27) acts as a tumor suppressor by inhibiting cyclin-cyclin-dependent kinase (cyclin-CDK) activity. However, mice expressing a form of p27 that is unable to bind or inhibit cyclin-CDK complexes (p27(CK-)) have increased incidence of tumor development as compared with wild-type...
Hilary Whitworth et al.
PloS one, 7(6), e38950-e38950 (2012-07-05)
As prostate cancer progresses to castration-resistant disease, there is an increase in signal transduction activity. Most castration-resistant prostate tumors continue to express the androgen receptor (AR) as well as androgen-responsive genes, despite the near absence of circulating androgen in these...
Marta Gai et al.
Molecular biology of the cell, 22(20), 3768-3778 (2011-08-19)
The small GTPase RhoA plays a crucial role in the different stages of cytokinesis, including contractile ring formation, cleavage furrow ingression, and midbody abscission. Citron kinase (CIT-K), a protein required for cytokinesis and conserved from insects to mammals, is currently...