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Anti-SLC12A2 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Anti-BSC, Anti-BSC2, Anti-NKCC1, Anti-PPP1R141
Human Protein Atlas Number:

biological source


Quality Level



antibody form

affinity isolated antibody

antibody product type

primary antibodies



product line

Prestige Antibodies® Powered by Atlas Antibodies


buffered aqueous glycerol solution

species reactivity



antibody small pack of 25 μL


immunohistochemistry: 1:500- 1:1000

immunogen sequence


UniProt accession no.

shipped in

wet ice

storage temp.


Gene Information

human ... SLC12A2(6558)

General description

Solute carrier family 12 member 2 (SLC12A2) is a member of the cation–chloride cotransporters (CCCs) family. The SLC12A2 gene is mapped to human chromosome 5q23.3. It is widely expressed in neurons and also in other organs especially, in the secretory epithelial cells. SLC12A2 exists as eight isoforms. It comprises 12 transmembrane (TM) helices and assembles into a dimer with TM11-TM12 helices lining the dimer interface.


Solute carrier family 12 member 2 recombinant protein epitope signature tag (PrEST)


All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-SLC12A2 antibody produced in rabbit has been used in immunofluorescence (1:1000).


25, 100 μL

Biochem/physiol Actions

Solute carrier family 12 member 2 (SLC12A2) also called Na-K-Cl cotransporter sodium-potassium-chloride cotransporter 1 (NKCC1) is a neuronal chloride importer and a neuronal chloride (Cl−) accumulator. It functions to regulate intraneuronal chloride levels along with KCC2. Mutations in the SLC12A2 are implicated in impaired secretory epithelia, encephalopathy, and neurodevelopmental disorders(NDD). It may serve as a potential target to treat neuropathic disorders, pain, and seizures.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.


Corresponding Antigen APREST74676.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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