HPA066315

Sigma-Aldrich

Anti-CXCL16 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):
Anti-SR-PSOX, Anti-SRPSOX, Anti-CXCLG16
Human Protein Atlas Number:

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

packaging

antibody small pack of 25 μL

application(s)

immunohistochemistry: 1:500- 1:1000

immunogen sequence

PVGSLSSDKELTRPNETTIHTAGHSLAAGPEAGENQKQPEKNAGPTARTSA

conjugate

unconjugated

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CXCL16(58191)

Related Categories

General description

C-X-C motif chemokine ligand 16 (CXCL16) is encoded by the gene mapped to human chromosome 17p13.2. The encoded protein is expressed in both transmembrane and soluble forms. CXCL16 belongs to the CXC chemokine family. CXCL16 is characterized with a chemokine domain followed by a glycosylated mucin-like stalk, a single transmembrane helix and an intracellular tail.

Immunogen

chemokine (C-X-C motif) ligand 16

Biochem/physiol Actions

C-X-C motif chemokine ligand 16 (CXCL16) expressed on transmembranes, facilitates lipid metabolism by acting as a scavenger receptor for oxidized low-density lipoprotein (oxLDL) uptake. Soluble form of CXCL16 acts as an attractant and adhesion molecule for CXCR6-expressing T cells, involved in the pathogenesis of atherosclerosis. CXCL16 expression is involved in the development of vascular, kidney and lung injury. Mutation in the gene increases the risk of susceptibility to myocardial infarction (MI). High levels of plasma CXCL16 has been observed in diabetic kidney disease patients.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST88180.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Circulating CXCL16 in Diabetic Kidney Disease.
Elewa U, et al.
Kidney & Blood Pressure Research, 41(5), 663-671 (2016)
The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a Chinese Han Population
Xu S, et al.
Disease Markers (2017)
?Inverse signaling? of the transmembrane chemokine CXCL16 contributes to proliferative and anti-apoptotic effects in cultured human meningioma cells
Hattermann K, et al.
Cell communication and signaling : CCS, 14(1), 26-26 (2016)
The chemokine and chemokine receptor superfamilies and their molecular evolution.
Zlotnik A
Genome Biology, 7(12), 243-243 (2006)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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