I0161

IWR-1

≥98% (HPLC), powder, Tankyrase1/2 inhibitor

• Synonym(s): 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-Benzamide, IWR1
• Empirical Formula (Hill Notation): C₂₅H₁₉N₃O₃
• CAS Number: 1127442-82-3
• Molecular Weight: 409.44
• UNSPSC Code: 12352200
• PubChem Substance ID: 329815302
• NACRES: NA.77

Properties

• Product Name: IWR-1, ≥98% (HPLC)
• Quality Level: 100
• assay: ≥98% (HPLC)
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear
• storage temp.: room temp
• SMILES string: O=C(Nc1cccc2cccnc12)c3ccc(cc3)N4C(=O)[C@@H]5[C@H]6C[C@H](C=C6)[C@@H]5C4=O
• InChI: 1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+
• InChI key: ZGSXEXBYLJIOGF-ALFLXDJESA-N

Description

Application

IWR-1 has been used as an antagonist for Wingless/Integrated (WNT) signaling pathway in human embryonic stem cells (hESCs),[1] mice lewis lung carcinoma (LLC)[2] and Sepia embryos.[3]

Biochem/physiol Actions

IWR-1 is a tankyrase inhibitor and is cytotoxic for cancer stem-like cells. It inhibits the in vivo progression of osteosarcoma.[4] IWR-1 interacts with RNA polymerase II and is crucial for the formation of preinitiation complex.[5]

The Wnt/b-catenin (‘canonical′) pathway maintains transcriptional programs that enable stem cells to remain multipotent.

The Wnt/b-catenin (‘canonical′) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable