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MilliporeSigma

I0523

Sigma-Aldrich

IL-2 mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Interleukin-2, T-cell growth factor, mIL-2, IL-2

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20 μG
$388.00

$388.00


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20 μG
$388.00

About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

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$388.00


In StockDetails


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Product Name

Interleukin-2 from mouse, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

mouse

Quality Level

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

≤0.2 ng/mL ED50

quality

endotoxin tested

mol wt

17.2 kDa

packaging

pkg of 5X20 μg
pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤1.000 EU/μg

color

white

UniProt accession no.

storage temp.

−20°C

Gene Information

mouse ... Il2(16183)

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This Item
I8523I9646I5271
assay

≥97% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

recombinant

expressed in E. coli

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in E. coli

recombinant

expressed in E. coli

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

200

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

General description

IL-2 (interleukin-2) codes for a pro-inflammatory cytokine.[1] IL-2 is mostly expressed in T helper cells.[2]

Application

Interleukin-2 from mouse has been used to induce sepsis in rat model.[2] It has also been used in dendritic epidermal T cell culture.[3]

Biochem/physiol Actions

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long-term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of natural killer cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor. IL-2 expression is known to reduce with age and results in influenza infection, neoplasms and lethal autoimmunity. IL-2 participates in T cell proliferation and differentiation and controls the homeostasis of T cell. As a part of immune response, IL-2 stimulates the action of T helper cell 1 and 2 along with endothelial white blood cells of skeletal muscles.[4][1] IL-2 regulation is controlled by c-rel protein.[4] IL-2 is a neurotrophic molecule and has special functions in cortical, hippocampal, septal, cerebellar and retinal neurons.[5]

Physical form

Lyophilized from a 0.2 μm filtered solution in 10 mM sodium citrate, pH 4.0.

Analysis Note

Activity was determined by dose-dependent stimulation of murine CTLL-2 cells. ED50 : ≤ 0.2 ng/ml (corresponds to a specific activity of 5 × 106 units/mg)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Questions

  1. Hi, I am wondering the real unit of your mouse IL2 in 20 ug. Could you please provide me with the number? thanks. best, Zebin

    1 answer
    1. The vial content and EC50 values are lot-specific and reported on the product Certificate of Analysis. The vial content will range from 20-26 µg and the EC50 will be a maximum of 0.2 ng/mL. An EC50 of 0.2 ng/ml corresponds to 5,000,000 units/mg.

      Please see the link below to review the product datasheet:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/347/154/i0523dat.pdf

      Please see the link below to access a lot specific or sample Certificate of Analysis:
      https://www.sigmaaldrich.com/product/sigma/I0523#product-documentation

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