I0879
Inosine 5′-triphosphate trisodium salt
≥95%
Synonym(s):
ITP
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About This Item
Empirical Formula (Hill Notation):
C10H12Na3N4O14P3
CAS Number:
Molecular Weight:
574.11
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥95%
Storage temp.:
−20°C
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InChI
1S/C10H15N4O14P3.Na.H/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20);;
SMILES string
[Na].OC1C(O)C(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n2cnc3C(=O)N=CNc23
InChI key
RIERCUPIZLBNFQ-UHFFFAOYSA-N
assay
≥95%
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... HRAS(3265)
Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| assay ≥95% | assay ≥80% | assay ≥95% | assay ≥96% |
| shipped in dry ice | shipped in wet ice | shipped in dry ice | shipped in - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information human ... HRAS(3265) | Gene Information human ... P2RY2(5029) | Gene Information - | Gene Information - |
Application
Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. ITP may be used as a substrate to study the specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to study activation of various ATPases and GTPases.
Inosine 5′-triphosphate trisodium salt has been used to investigate its influence on the chromosome aberration rate, the mitotic rate, sister-chromatid exchange (SCE) frequency, the proportion of first (X1), second (X2) and third (X3) division metaphases of human peripheral lymphocytes.[1]
Biochem/physiol Actions
Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD). ITP can proficiently induce secretion in permeabilized cells than GTP.[2] Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription.[3] ITP can also replace GTP in the activation of G-protein.[2]
Preparation Note
Prepared from Bacterial ATP
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Initiation of reovirus transcription by inosine 5'-triphosphate and properties of 7-methylinosine-capped, inosine-substituted messenger ribonucleic acids
Morgan M A and Shatkin A J
Biochemistry, 19(26), 5960-5966 (1980)
Man Liu et al.
The Journal of biological chemistry, 278(12), 10112-10118 (2003-01-23)
Infrared spectroscopy has been used to map substrate-protein interactions: the conformational changes of the sarcoplasmic reticulum Ca(2+)-ATPase upon nucleotide binding and ATPase phosphorylation were monitored using the substrate ATP and ATP analogues (2'-deoxy-ATP, 3'-deoxy-ATP, and inosine 5'-triphosphate), which were modified
Itallo Collopy Junior et al.
FEMS yeast research, 5(10), 899-907 (2005-06-14)
Cryptococcus neoformans is the causative agent of pulmonary cryptococcosis and cryptococcal meningoencephalitis, which are major clinical manifestations in immunosuppressed patients. In the present study, a surface ATPase (ecto-ATPase) was identified in C. neoformans yeast cells. Intact yeasts hydrolyzed adenosine-5'-triphosphate (ATP)
Functionally nonequivalent interactions of guanosine 5?-triphosphate, inosine 5?-triphosphate, and xanthosine 5?-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes
Klinker J F and Seifert R
Biochemical Pharmacology, 54(5), 551-562 (1997)
A Baracca et al.
The International journal of biochemistry, 25(5), 701-706 (1993-05-01)
1. The possibility that the rate of ATP hydrolysis by F1-ATPase approaches the diffusion-controlled limits was investigated by measuring the values of kcat and kl (kcat/Km) as a function of increasing viscosity. 2. The values of kcat/Km decrease significantly with
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