I0884

Sigma-Aldrich

Anti-Human IgA (α-chain specific) antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(s):
Anti Human IgA Antibody - Anti-Human IgA (α-chain specific) antibody produced in goat, Anti Human Iga
MDL number:
NACRES:
NA.46

Quality Level

biological source

goat

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

lyophilized powder

application(s)

Ouchterlony double diffusion: suitable

conjugate

unconjugated

storage temp.

2-8°C

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General description

Immunoglobulin A (IgA) is the primary antibody involved in mucosal immunity. It is identified by the presence of α-type heavy chains. IgA which is composed of two subclasses IgA1 and IgA2 can exist in a dimeric secretory form found in mucous secretions.
IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. Thus secretory IgA contributes to the humoral defense mechanism against the pathogens on mucosal surfaces
Anti-Human IgA (α-chain specific) antibody specifically recognizes human IgA.
Specificity for the α-chain of human IgA is determined by Ouchterlony Double Diffusion (ODD). The antibody preparation is specific for human IgA when tested against purified human IgA, IgG, IgM, Bence Jones kappa and Bence Jones λ myeloma proteins.

Immunogen

Purified human IgA

Application

Anti-Human IgA (α-chain specific) antibody is suitable for Ouchterlony double diffusion. The antibody was used for IgA quantification by ELISA in various studies. Antibody dilution of 1:4000 was used for passive hemagglutination inhibition assay.
Goat polyclonal anti-human IgA (α-chain specific) antibody may be used to locate and identify the α-chain of human IgA by immunocytochemical and immunohistochemical (IHC) techniques.

Physical form

Lyophilized from 0.01 M sodium phosphate, 0.015 M sodium chloride, pH 7.2

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Leif K Nielsen et al.
Transfusion, 48(9), 1892-1897 (2008-06-03)
To avoid anaphylactic reactions, immunoglobulin (Ig)A-deficient patients with anti-IgA should be transfused with IgA-deficient blood components. There is a need for fast and robust assays for demonstration of IgA deficiency and for detection of anti-IgA. Recombinant human IgA1 and IgA2...
Dan Ericson et al.
Pathogens and disease, 68(3), 82-87 (2013-06-06)
We investigated whether ingestion of probiotic bacteria could influence salivary IgA levels, specific anti-mutans streptococci IgA levels and specific antibodies towards the ingested probiotic bacterium. The study was a randomised, double-blind, placebo-controlled trial, where the test group (n = 11) received twice...
Hannah Andersson et al.
International journal of microbiology, 2016, 8469018-8469018 (2017-01-20)
Objective. To clarify the effect of Lactobacillus plantarum 299v on the salivary cortisol and salivary IgA levels in young adults under examination stress. Design. Forty-one students with an upcoming academic exam were included in a randomized double-blind, placebo-controlled study. The...
Mikael Sonesson et al.
European journal of oral sciences, 119(1), 15-20 (2011-01-20)
According to previous studies, minor glands produce about 35% of the total salivary immunoglobulin A (salivary IgA). The age-dependent increase in whole-saliva salivary IgA concentrations has been studied extensively, but we found no published reports comparing the minor-gland saliva concentrations...
L C Torres et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 43(12), 1215-1224 (2010-11-19)
Rubinstein-Taybi syndrome (RTS) is a rare developmental disorder characterized by craniofacial dysmorphisms, broad thumbs and toes, mental and growth deficiency, and recurrent respiratory infections. RTS has been associated with CREBBP gene mutations, but EP300 gene mutations have recently been reported...

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