I1010

Sigma-Aldrich

IgA from human colostrum

reagent grade, ≥95%, essentially salt-free, lyophilized powder

Synonym(s):
Human IgA
MDL number:
NACRES:
NA.46
Pricing and availability is not currently available.

Quality Level

grade

reagent grade

assay

≥95%

form

essentially salt-free, lyophilized powder

conjugate

unconjugated

storage temp.

2-8°C

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General description

IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears, colostrum and saliva. Thus secretory IgA contributes to the humoral defense mechanism against the pathogens on mucosal surfaces
Human IgA is purified from pooled normal human colostrum by fractionation and ion-exchange fractionation.

Application

Purified IgA may be used as a reference antigen, standard, blocking agent or coating protein in a variety of immunoassays including ELISA, dot immunobinding, immunoblotting, immunodiffusion and immunoelectrophoresis. Other applications include starting materials for the preparation of immunogens and solidphase immunoadsorbents. IgA from human colostrum was used as a standard in ELISA (1 mg/ml) and gel electrophoresis.

Packaging

5, 25 mg in glass bottle

Reconstitution

Reconstitute with buffered saline (150 mM sodium chloride).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
E Knop et al.
Investigative ophthalmology & visual science, 42(3), 566-574 (2001-02-27)
Mucosa-associated lymphoid tissue (MALT) specifically protects mucosal surfaces. In a previous study of the human conjunctiva, evidence was also found for the presence of MALT in the lacrimal sac. The present study, therefore, aims to investigate its morphology and topographical...
null
P Kosuwon et al.
Beneficial microbes, 9(4), 541-552 (2018-04-11)
Little is known about the impact of nutrition on toddler gut microbiota. The plasticity of the toddler gut microbiota indicates that nutritional modulation beyond infancy could potentially impact its maturation. The objective of this study was to determine the effect...
Plasma IgA antibody levels to malondialdehyde acetaldehyde-adducts are associated with inflammatory mediators, obesity and type 2 diabetes.
Vehkala, et al.
Annals of Medicine, 45, 501-510 (2017)
A M Bakker-Zierikzee et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 17(2), 134-140 (2006-04-19)
Secretory immunoglobulin A (SIgA) plays an important role in the defence of the gastrointestinal tract. The level of faecal SIgA antibody is associated with increased neutralization and clearance of viruses. Formula-fed infants who lack the transfer of protective maternal SIgA...

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