I1020

IL-4 mouse

Name: IL-4 mouse
Brand: SIGMA
Price: 187 USD
Availability: InStock

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Interleukin-4, mIL-4, Interleukin-4 human

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5 μG

$187.00

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About This Item

MDL number:

MFCD00166698

UNSPSC Code:

12352202

NACRES:

NA.77

Key Documents

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Product Name

Interleukin-4 from mouse, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

mouse

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized powder

potency

0.1-2.0 ng/mL ED₅₀/EC₅₀

quality

endotoxin tested

mol wt

~13.5 kDa

packaging

pkg of 5 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg

UniProt accession no.

P07750

storage temp.

−20°C

Gene Information

mouse ... Il4(16189)

Related Categories

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Growth Factors and Cytokines

Molecular Biology & Functional Genomics

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Show Differences

1 of 4

This Item	I3650	I5396	I4269
Sigma-Aldrich I1020 Interleukin-4 from mouse	Sigma-Aldrich I3650 Interleukin-4 from rat	Sigma-Aldrich I5396 Interleukin-1α from mouse	Sigma-Aldrich I4269 Interleukin-4 human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
assay ≥98% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥98% (SDS-PAGE)
biological source mouse	biological source rat	biological source mouse	biological source human
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

Application

Interleukin-4 from mouse has been used:

as a component of cell culture media for class switch recombination assay[1]
to study its therapeutic benefits for mucosal healing[2]
as a pioglitazone or new peroxisome proliferator-activated receptor agonist (GQ-11)[3]

Biochem/physiol Actions

Interleukin-4 (IL-4) is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and FGF-Basic-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Treatment of IL-4 with specific glycosidases yields an active polypeptide. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.

Interleukin-4, a lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and bFGF-induced angiogenesis. Human and mouse IL-4 share 50% amino acid sequence identity, but their biological actions are species-specific.

Physical form

Lyophilized, 0.2 μm filtered, with no additives.

Analysis Note

The proliferative activity is tested in culture using mouse HT-2 cells.[4]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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New Peroxisome Proliferator-Activated Receptor Agonist (GQ-11) Improves Wound Healing in Diabetic Mice

Silva JC, et al.

Advances in Wound Care (2019)

Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells

Sharba S, et al.

Virulence, 10(1), 97-117 (2019)

VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells

Khan AJ, et al.

Oncotarget, 9(40), 25833-25833 (2018)

Genomic patterns of transcription-replication interactions in mouse primary B cells.

Commodore P St Germain et al.

Nucleic acids research, 50(4), 2051-2073 (2022-02-01)

Conflicts between transcription and replication machinery are a potent source of replication stress and genome instability; however, no technique currently exists to identify endogenous genomic locations prone to transcription-replication interactions. Here, we report a novel method to identify genomic loci

B cell-stimulatory factor 1 (BSF-1) promotes growth of helper T cell lines.

R Fernandez-Botran et al.

The Journal of experimental medicine, 164(2), 580-593 (1986-08-01)

T cell-derived supernatants (SN) that contain B cell-stimulatory factor 1 (BSF-1) and lack IL-2 promote the growth of the IL-2-dependent T cell line, HT-2, as well as three other clones or lines of T cells that can provide help to

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