This product is a whole antiserum. The antibody concentration varies from lot to lot and ranges from 3.0 - 5.0 mg/mL. This information is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/i1261#product-docuemntation
I1261
Anti-Human IgA (α-chain specific) antibody produced in goat
whole antiserum
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), QPA
Citations:
8
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biological source
goat
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
secondary antibodies
clone
polyclonal
contains
15 mM sodium azide
technique(s)
indirect ELISA: 1:50,000, quantitative precipitin assay: 3.0-5.0
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
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Related Categories
1 of 4
This Item | I8885 | I1011 | I1136 |
|---|---|---|---|
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| antibody form whole antiserum | antibody form whole antiserum | antibody form whole antiserum | antibody form whole antiserum |
| technique(s) indirect ELISA: 1:50,000, quantitative precipitin assay: 3.0-5.0 | technique(s) indirect ELISA: 1:50,000, quantitative precipitin assay: 4.0-7.0 mg/mL | technique(s) indirect ELISA: 1:40,000, quantitative precipitin assay: 4.0 mg/mL | technique(s) indirect ELISA: 1:40,000, quantitative precipitin assay: 4.0 mg/mL |
| biological source goat | biological source goat | biological source goat | biological source goat |
| clone polyclonal | clone polyclonal | clone polyclonal | clone polyclonal |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
General description
Immunoglobulin A (IgA) is found as two subclasses, that is, IgA1 and IgA2. IgA exists as a monomer or dimer in the secreted form. Dimeric IgA has a molecular weight of 390 kDa.
Application
Anti-Human IgA (α-chain specific) antibody produced in goat has been used to determine the concentration of total IgA in serum samples by single radial immunodiffusion and enzyme-linked immunosorbent assay (ELISA).
Biochem/physiol Actions
IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. Thus secretory IgA contributes to the humoral defense mechanism against the pathogens on mucosal surfaces.
In addition to passive immunity, IgA also induces active immunity by regulating the production of various chemokines and vital cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-1β.
The antibody preparation is specific for human IgA when tested against purified human IgA, IgG, IgM, Bence Jones Kappa, and Bence Jones Lambda myeloma proteins
Physical form
Goat Anti-Human IgA is supplied as a liquid containing 0.1% sodium azide as preservative.
Preparation Note
For continuous use, store at 2-8 °C for a maximum of one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ivo S Hansen et al.
Cellular and molecular life sciences : CMLS, 76(6), 1041-1055 (2018-12-01)
The prevailing concept regarding the immunological function of immunoglobulin A (IgA) is that it binds to and neutralizes pathogens to prevent infection at mucosal sites of the body. However, recently, it has become clear that in humans IgA is also
Kinetic Analysis of Interaction of Different Types of Rheumatoid Factors with Immobilized IgG Using Surface PlasmonResonance
Matsumoto A, et al.
The Journal of Biological Chemistry, 128(6), 1009-1016 (2000)
Eva Michaud et al.
EMBO molecular medicine, 14(8), e15386-e15386 (2022-07-06)
Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward tolerance or inflammation, notably through reverse-transcytosis, the apical-to-basal transport of IgA2 immune complexes via M cells of gut Peyer's patches. As such, the maintenance of a diverse gut microbiota
L C Torres et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 43(12), 1215-1224 (2010-11-19)
Rubinstein-Taybi syndrome (RTS) is a rare developmental disorder characterized by craniofacial dysmorphisms, broad thumbs and toes, mental and growth deficiency, and recurrent respiratory infections. RTS has been associated with CREBBP gene mutations, but EP300 gene mutations have recently been reported
Ketil Moen et al.
Clinical and diagnostic laboratory immunology, 10(6), 1043-1050 (2003-11-11)
The objective of the present study was to investigate immunoglobulin G (IgG) and IgA antibody immune responses to Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, and Candida albicans in the sera of patients with rheumatoid arthritis (RA), the synovial fluid (SF)
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