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Sigma-Aldrich

Intralipid

emulsion, lipid emulsion

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Synonym(s):
Phospholipid stabilized soybean oil
CAS Number:
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.77

form

emulsion

Quality Level

concentration

20%

color

white

storage temp.

2-8°C

Application

Intralipid has been used:
  • for testing its optical properties to be used as scattering medium for tissue phantom generation
  • as a component of agarose gel phantom to reduce scatter coefficients and background absorption
  • in infusion into mice in hyperinsulinemic-euglycemic clamps studies to evaluate its effect on nonesterified free fatty acids (NEFA) circulation

Biochem/physiol Actions

Intralipid is a lipid emulsion comprising soybean oil. It favors proinflammatory cytokines production and is recommended for the treatment of immune-mediated pregnancy and implantation failure. In parenteral nutrition, intralipid is the source of fats. It elicits protection in heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. Intralipid is an effective alternative for intravenous immunoglobulin and improves bioavailability of platinum based anti-cancer drugs.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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USP

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Sigma-Aldrich

Sigma-Aldrich

L5146

Lipid Mixture (1000×)

Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A
Li J, et al.
Anesthesiology, 117(4), 836-846 (2012)
Birgitta I Zielbauer et al.
Journal of colloid and interface science, 529, 197-204 (2018-06-13)
Oleosomes are stabilized by a complex outer phospholipid-protein-layer. To improve understanding of its structure and stabilization mechanism, this shell has to be studied in extracellular native conditions. This should be possible by SANS using contrast variation. Oleosomes are expected to
Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice
Xu W, et al.
Molecular and Cellular Endocrinology, 482(22), 1-10 (2019)
Lisa R Beutler et al.
eLife, 9 (2020-07-29)
Body weight is regulated by interoceptive neural circuits that track energy need, but how the activity of these circuits is altered in obesity remains poorly understood. Here we describe the in vivo dynamics of hunger-promoting AgRP neurons during the development
Benedict Mc Larney et al.
Journal of biophotonics, 12(6), e201800387-e201800387 (2019-02-01)
Accurate image reconstruction in volumetric optoacoustic tomography implies the efficient generation and collection of ultrasound signals around the imaged object. Non-uniform delivery of the excitation light is a common problem in optoacoustic imaging often leading to a diminished field of

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