Skip to Content
MilliporeSigma

I2142

KN-62

≥95%, powder

Synonym(s):

(S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine

Slide 1 of 1
Sign In to View Organizational & Contract Pricing.

Select a Size

0.5 MG

$146.00

1 MG

$218.00

$146.00

Check Cart for Availability
Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):
C38H35N5O6S2
CAS Number:
127191-97-3
Molecular Weight:
721.84
NACRES:
NA.77
PubChem Substance ID:
24895961
UNSPSC Code:
12352200
MDL number:
MFCD00083180

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI

1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1

SMILES string

O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O

InChI key

RJVLFQBBRSMWHX-DHUJRADRSA-N

biological source

synthetic (organic)

assay

≥95%

form

powder

color

yellow

mp

130 °C

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL, methanol: 10 mg/mL, DMSO: 12 mg/mL, chloroform: 20 mg/mL

storage temp.

−20°C

Quality Level

200

Gene Information

human ... P2RX7(5027)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
422706SML2384S8010
KN-62 ≥95%, powder

Sigma-Aldrich

I2142

KN-62

KN-62 A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme.

Sigma-Aldrich

422706

KN-62

BAY 87-2243 ≥98% (HPLC)

Sigma-Aldrich

SML2384

BAY 87-2243

(±)-Sulpiride

Sigma-Aldrich

S8010

(±)-Sulpiride

assay

≥95%

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

-

form

powder

form

solid

form

powder

form

powder

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL, DMSO: 12 mg/mL, methanol: 10 mg/mL, chloroform: 20 mg/mL

solubility

methanol: 5 mg/mL, DMSO: soluble

solubility

DMSO: 2 mg/mL, clear

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL, 0.1 M HCl: soluble, H2O: slightly soluble, ethanol: soluble

color

yellow

color

off-white

color

white to beige

color

white

Biochem/physiol Actions

Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.

Features and Benefits

This compound is featured on the Ca/CaMKs and P2 Receptors: P2X Ion Channel Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000323633
0000323633
0000371907
0000371908
0000332918

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Antagonists of the P2X(7) receptor. From lead identification to drug development.
Simon D Guile et al.
Journal of medicinal chemistry, 52(10), 3123-3141 (2009-02-05)
Regina Stark et al.
Science immunology, 3(30) (2018-12-16)
Tissue-resident memory T cells (TRM) are noncirculating immune cells that contribute to the first line of local defense against reinfections. Their location at hotspots of pathogen encounter frequently exposes TRM to tissue damage. This history of danger-signal exposure is an
Nikki Jo-Hao Weng et al.
Stem cell research, 23, 39-49 (2017-07-04)
New methods are needed to reduce dynamic blebbing which inhibits cell attachment and survival during passaging of pluripotent stem cells. We tested the hypothesis that activation of the P2X7 receptor by extracellular ATP during passaging initiates dynamic blebbing. The P2X7
G H Fan et al.
Molecular pharmacology, 56(1), 39-45 (1999-07-01)
Learning and memory have been suggested to be important in the development of opiate addiction. Based on the recent findings that calcium/calmodulin-dependent protein kinase II (CaMKII) is essential in learning and memory processes, and morphine treatment increases CaMKII activity in
R J MacLeod et al.
The Journal of membrane biology, 172(1), 59-66 (1999-11-07)
To assess the activation of the charybdotoxin-insensitive K(+) channel responsible for Regulatory Volume Decrease (RVD) after substantial volume increases, we measured intracellular pH (pH(i)), intracellular calcium ([Ca(2+)](i)) and inhibitors of kinases and phosphoprotein phosphatases in guinea pig jejunal villus enterocytes
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service