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I2644

Sigma-Aldrich

Interleukin-2 human

IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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Synonym(s):
IL-2, hIL-2, Interleukin-2, T-cell growth factor
MDL number:
NACRES:
NA.77

biological source

human

Quality Level

recombinant

expressed in E. coli

form

lyophilized powder

potency

≤700 EC50

quality

endotoxin tested

mol wt

15.5 kDa

packaging

pkg of 5X10 μg
pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... IL2(3558)

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This Item
H704157600H7666
Sigma-Aldrich

Sigma-Aldrich

I2644

Interleukin-2 human

Interleukin-2 human IL-2, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested

Sigma-Aldrich

H7041

Interleukin-2 human

Sigma-Aldrich

Sigma-Aldrich

57600

Interleukin-2 human

Sigma-Aldrich

Sigma-Aldrich

H7666

Interleukin-12 human

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

form

lyophilized powder

form

lyophilized powder

form

liquid

form

lyophilized

potency

≤700 EC50

potency

≤5.0 ng/mL ED50

potency

-

potency

≤2 ng/mL EC50

mol wt

15.5 kDa

mol wt

monomer 15 kDa (glycosylated)

mol wt

Mr ~15500

mol wt

dimer 57 kDa (glycosylated)

packaging

pkg of 5X10 μg, pkg of 10 μg

packaging

pkg of 5X10 μg, pkg of 10 μg, pkg of 100 μg

packaging

vial of 1 mL

packaging

pkg of 10 μg

General description

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

Application

Interleukin-2 human has been used:
  • in the stimulation of natural killer cells
  • to study its ability to stimulate lymphocyte growth and prevent apoptosis
  • as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus

Biochem/physiol Actions

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. It mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized, 0.2 μm filtered, no additives.

Analysis Note

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Articles

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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