I3657

Insulin-Like Growth Factor Binding Protein-2 from mouse

Name: Insulin-Like Growth Factor Binding Protein-2 from mouse
Brand: SIGMA
Price: 850 USD
Availability: InStock

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonym(s):

IGFBP-2

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25 μG

$850.00

Estimated to ship onMarch 16, 2026Details

About This Item

UNSPSC Code:

51111800

NACRES:

NA.32

MDL number:

MFCD02099094

Key Documents

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biological source

mouse

Quality Level

200

recombinant

expressed in NSO cells

assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

0.125-0.5 mg per mL ED₅₀

mol wt

~35 kDa by SDS-PAGE (reducing), calculated mol wt 29.4 kDa

packaging

pkg of 25 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

D3YU40

storage temp.

−20°C

Gene Information

mouse ... Igfbp2(16008)

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This Item	I5403	I8529	I5278
Sigma-Aldrich I3657 Insulin-Like Growth Factor Binding Protein-2 from mouse	Sigma-Aldrich I5403 Insulin-Like Growth Factor Binding Protein-2 human	Sigma-Aldrich I8529 Insulin-like Growth Factor Binding Protein-5 human	Sigma-Aldrich I5278 Insulin-Like Growth Factor Binding Protein-3 human
recombinant expressed in NSO cells	recombinant expressed in NSO cells	recombinant expressed in NSO cells	recombinant expressed in NSO cells
biological source mouse	biological source human	biological source human	biological source human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) -	technique(s) cell culture \| mammalian: suitable
assay ≥95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay >90% (SDS-PAGE)	assay ≥95% (SDS-PAGE)
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

General description

IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains.[1][2] It is a secreted protein.[3]

Biochem/physiol Actions

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.

Exhibits a 2-10 fold higher affinity for IGF II than for IGF I.

IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation.[4] It mainly binds to IGFs and restricts their association to other receptors.[1][2]

Physical form

Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The coordinate cellular response to insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-2 (IGFBP-2) is regulated through vimentin binding to receptor tyrosine phosphatase β (RPTPβ).

Xinchun Shen et al.

The Journal of biological chemistry, 290(18), 11578-11590 (2015-03-20)

Insulin-like growth factor-binding protein-2 (IGFBP-2) functions coordinately with IGF-I to stimulate cellular proliferation and differentiation. IGFBP-2 binds to receptor tyrosine phosphatase β (RPTPβ), and this binding in conjunction with IGF-I receptor stimulation induces RPTPβ polymerization leading to phosphatase and tensin

Regulation of IGFBP-2 expression during fasting.

Hye Suk Kang et al.

The Biochemical journal, 467(3), 453-460 (2015-02-20)

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In

The heparin-binding domains of IGFBP-2 mediate its inhibitory effect on preadipocyte differentiation and fat development in male mice.

Gang Xi et al.

Endocrinology, 154(11), 4146-4157 (2013-08-29)

IGF-binding protein (IGFBP)-2 overexpression confers resistance to high-fat feeding and inhibits the differentiation of preadipocytes in vitro. However, whether administration of IGFBP-2 can regulate adipogenesis in vivo and the domains that mediate this response have not been defined. IGFBP-2 contains

IGFBP-2 directly stimulates osteoblast differentiation.

Gang Xi et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 29(11), 2427-2438 (2014-05-20)

Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation. MC-3T3 preosteoblasts

Global Trade Item Number

SKU	GTIN
I3657-25UG	04061833856246

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