I3784

IgG3, Kappa from murine myeloma

Name: IgG3, Kappa from murine myeloma
Brand: SIGMA
Price: 312 USD

clone DX, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Mouse IgG3-κ

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1 MG

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.46

MDL number:

MFCD00164803

Key Documents

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Product Name

IgG3, Kappa from murine myeloma, clone DX, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

clone

DX, monoclonal

assay

≥95% (microfluidic capillary gel electrophoresis)

form

buffered aqueous solution

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

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Show Differences

1 of 4

This Item	M9019	I5529	I5154
Sigma-Aldrich I3784 IgG3, Kappa from murine myeloma	Sigma-Aldrich M9019 IgG3, Lambda from murine myeloma	Sigma-Aldrich I5529 IgG3, Lambda from human myeloma plasma	Sigma-Aldrich I5154 IgG1, Kappa from human myeloma plasma
clone DX, monoclonal	clone Y5606, monoclonal	clone -	clone -
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
biological source mouse	biological source mouse	biological source human	biological source human
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
form buffered aqueous solution	form buffered aqueous solution	form -	form -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200

Application

IgG3, κ from murine myeloma was used as blocking agent in immunofluorescence labeling of larval and adult Echinococcus multilocularis worms.[1] It was used as negative control in assay to study the surface binding of antibodies to meningococci.[2]

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections.[3] IgG3 is the has a unique extended hinge region conferring greater flexibility
IgG3, κ from murine myeloma specifically recognizes mouse IgG3. Specificity of the mouse IgG3, κ is determined by immunodiffusion and IEP techniques. The purified myeloma preparation is non-reactive with antisera to mouse IgA, IgM, IgD, IgG1, IgG2a and IgG2b.

Physical form

Solution in Tris buffered saline, pH 7.2, containing 0.1% sodium azide.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Immunoproteomic identification of the hypothetical protein NMB1468 as a novel lipoprotein ubiquitous in Neisseria meningitidis with vaccine potential.

Chi-An Hsu et al.

Proteomics, 8(10), 2115-2125 (2008-05-21)

Many potential vaccine candidates for serogroup B Neisseria meningitidis (NMB) have been identified by reverse vaccinology, a genome-based approach. However, some candidates may be unseen owing to uncertain annotation or their peculiar properties. In this study, we describe the preparation

An Echinococcus multilocularis coproantigen is a surface glycoprotein with unique O-gycosylation.

Andreas J Hülsmeier et al.

Glycobiology, 20(1), 127-135 (2009-10-14)

A major surface constituent of Echinococcus multilocularis adult worms, referred to as an EmA9 antigen, was immunoaffinity purified and identified as a high-molecular-weight glycoconjugate. Labeling studies using the monoclonal antibody MAbEmA9 indicated that this antigen undergoes a regulated expression during

IgEb immune complexes activate macrophages through FcgammaRIV binding.

Masayuki Hirano et al.

Nature immunology, 8(7), 762-771 (2007-06-15)

Because functional analysis of Fc receptors (FcRs) relies heavily on mouse models, the identification of another Fcgamma receptor is particularly noteworthy. We demonstrate that FcgammaRIV, identified here as the mouse ortholog of primate FcgammaRIII, required association of the FcR gamma-chain

Differentiation of rat multipotent adult progenitor cells to functional hepatocyte-like cells by mimicking embryonic liver development.

Philip Roelandt et al.

Nature protocols, 5(7), 1324-1336 (2010-07-03)

Differentiation of stem cells to hepatocytes has industrial applications, as well as the potential to develop new therapeutic strategies for liver disease. The protocol described here, sequentially using cytokines that are known to have a role in liver embryonic development

Placental transfer of IgG subclasses in a Japanese population.

S Hashira et al.

Pediatrics international : official journal of the Japan Pediatric Society, 42(4), 337-342 (2000-09-15)

Maternal immunoglobulin G (IgG), transferred across the placenta to the fetus during intrauterine life, is an important component of the neonatal immunological defence mechanisms against infection. There is controversy with respect to differences in placental transfer of the different IgG

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