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I3901

Sigma-Aldrich

Interleukin-1α from rat

IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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Synonym(s):
rIL-1α, IL-1α, Lymphocyte activating factor
MDL number:
MFCD01635091
NACRES:
NA.77

biological source

rat

Quality Level

100

recombinant

expressed in E. coli

Assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

1-10 pg/mL EC50

quality

endotoxin tested

mol wt

~18 kDa

packaging

pkg of 5 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤0.1 EU/μg

UniProt accession no.

P16598

storage temp.

−20°C

Gene Information

rat ... Il1a(24493)

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Interleukin-1β from rat

Interleukin-1β from mouse IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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I5271

Interleukin-1β from mouse

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I5396

Interleukin-1α from mouse

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

assay

≥98% (SDS-PAGE and HPLC)

assay

≥97% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

potency

1-10 pg/mL EC50

potency

0.01-0.1 ng/mL ED50/EC50

potency

≤0.010 ng/mL ED50

potency

3-7 pg/mL ED50

mol wt

~18 kDa

mol wt

17.3 kDa

mol wt

17.5 kDa (containing 153 amino acid residues)

mol wt

18 kDa

Biochem/physiol Actions

Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LA F), activates T cells and lymphocytes, which then proliferate and secrete Interleukin-2 (IL-2). The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

Physical form

Lyophilized from 0.2 μm filtered phosphate buffered saline containing 0.25 mg of bovine serum albumin.

Analysis Note

The biological activity of recombinant rat IL-1α was measured by its ability to stimulate cell proliferation using a mouse helper T cell line, D10.G4.1.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Xuankang Wang et al.
Frontiers in neuroscience, 15, 768262-768262 (2021-11-20)
After spinal cord injury (SCI), reactive astrocytes can be classified into two distinctive phenotypes according to their different functions: neurotoxic (A1) astrocytes and neuroprotective (A2) astrocytes. Our previous studies proved that photobiomodulation (PBM) can promote motor function recovery and improve
T Nishida et al.
Journal of biochemistry, 105(3), 351-357 (1989-03-01)
A cDNA sequence coding for rat interleukin-1 alpha (IL-1 alpha) has been isolated from a cDNA library that was prepared with mRNA derived from LPS-stimulated rat peritoneal macrophages by using human IL-1 alpha cDNA as a probe. The rat cDNA
Xuankang Wang et al.
Journal of neuroinflammation, 18(1), 256-256 (2021-11-07)
Neurotoxic microglia and astrocytes begin to activate and participate in pathological processes after spinal cord injury (SCI), subsequently causing severe secondary damage and affecting tissue repair. We have previously reported that photobiomodulation (PBM) can promote functional recovery by reducing neuroinflammation
Sualyneth Galarza et al.
Advanced healthcare materials, 9(4), e1901419-e1901419 (2020-01-17)
Bioengineers have designed numerous instructive brain extracellular matrix (ECM) environments with tailored and tunable protein compositions and biomechanical properties in vitro to study astrocyte reactivity during trauma and inflammation. However, a major limitation of both protein-based and synthetic model microenvironments
Shuqi Jiang et al.
Journal of inflammation research, 14, 5919-5937 (2021-11-23)
Astrocyte A1/A2 phenotypes may play differential role in the pathogenesis of periventricular white matter (PWM) damage in septic postnatal rats. This study aimed to determine whether melatonin (MEL) would improve the axonal hypomyelination through shifting A1 astrocytes towards A2. One-day-old
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