Human IgA exists in 2 forms. It is a monomer in the serum and a dimer in mucosal secretory tissues [secretory IgA (sIgA)]. Secretory IgA is a complex comprising two IgA monomers, a connecting J chain, and a secretory component.
I4036
IgA from human serum
reagent grade, ≥95% (HPLC), buffered aqueous solution
Synonym(s):
Human IgA
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1 MG
$125.00
5 MG
$588.39
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
conjugate
unconjugated
grade
reagent grade
assay
≥95% (HPLC)
form
buffered aqueous solution
storage temp.
−20°C
1 of 4
This Item | I2511 | 401098 | I8260 |
|---|---|---|---|
| form buffered aqueous solution | form buffered aqueous solution | form liquid | form buffered aqueous solution |
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (SDS-PAGE) | assay ~95% (HPLC) |
| Quality Level 300 | Quality Level 300 | Quality Level 200 | Quality Level 300 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| conjugate unconjugated | conjugate unconjugated | conjugate - | conjugate unconjugated |
| grade reagent grade | grade reagent grade | grade - | grade reagent grade |
General description
IgA is one of the most abundant antibody isotypes produced in the body. It is mainly secreted by plasma cells located in the lamina propria. There are two subtypes of IgA, IgA1 and IgA2 present primarily in the airways and colon, respectively.
Application
IgA from human serum has been used in enzyme-linked immunosorbent assay (ELISA) for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-spike-receptor binding domain (RBD) antibody detection in blood samples.
Purified human IgA may be used to study its physiological and biological effects on processes such as inflammation, pathogen elimination, regulation of antibody-dependent-cell-mediated cytotoxicity (ADCC), modulation of phagocytosis, degranulation of eosinophils and basophils and modulation of respiratory burst activity.
Biochem/physiol Actions
IgA aids in inducing a defense mechanism against various viral pathogens such as rotavirus, poliovirus, influenza virus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It regulates excessive immune responses in inflammatory diseases. IgA also has the potential to trigger neutrophil recruitment for cell killing.
Physical form
Solution in 0.01 M Phosphate Buffer saline, pH 7.4, containing 15 mM sodium azide as a preservative.
Storage Class
12 - Non Combustible Liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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What is the isoform of the IgA? Is it only in its dimeric form or is it a mix of the monomer and the dimer?
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