I4409
Fulvestrant
>98% (HPLC)
Synonym(s):
(7α,17β)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol, Faslodex, ICI 182,780, ZD 182780, ZD 9238, ZM 182780
About This Item
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assay
>98% (HPLC)
form
powder
solubility
DMSO: >5 mg/mL
originator
AstraZeneca
storage temp.
2-8°C
SMILES string
[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)Cc4cc(O)ccc24
InChI
1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
InChI key
VWUXBMIQPBEWFH-WCCTWKNTSA-N
Gene Information
human ... ESR1(2099) , ESR2(2100)
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Application
- as an antagonist of estrogen receptor (ERα and ERβ) to reduce hepatocytes proliferation
- as an antagonist of ER for the suppression of estrogen responsive element in human breast cancer MCF-7 cells
- as anti-estrogen in breast cancer cell lines
Biochem/physiol Actions
Features and Benefits
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