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I4883

Sigma-Aldrich

Ibuprofen

≥98% (GC)

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Synonym(s):
2-(4-Isobutylphenyl)propanoic acid, Brufen, Motrin, Rebugen, α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid
Empirical Formula (Hill Notation):
C13H18O2
CAS Number:
Molecular Weight:
206.28
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

assay

≥98% (GC)

form

powder

mp

77-78  °C

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

SMILES string

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

InChI key

HEFNNWSXXWATRW-UHFFFAOYSA-N

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1 of 4

This Item
1335508Y0000881I110
vibrant-m

I4883

Ibuprofen

vibrant-m

1335508

Ibuprofen

vibrant-m

I110

Ibuprofen

form

powder

form

-

form

-

form

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

solubility

-

solubility

-

solubility

-

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

mp

77-78  °C

mp

-

mp

-

mp

-

General description

Ibuprofen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) known for its pain-relieving, anti-inflammatory, and fever-reducing properties. It can hinder the effectiveness of various antihypertensive medications, including β-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and diuretics. Ibuprofen exists in an unbound state in cerebrospinal fluid and is accumulated in the synovial fluid of inflamed joints in arthritis patients.

Application

Ibuprofen has been used:
  • to study its vascular and pulmonary effects on neonatal lung development
  • to study its effects on cell apoptosis, cell proliferation, and histology changes in human cholangiocarcinoma cell lines
  • in the preparation of a terpene-based therapeutic deep eutectic system (THEDES) to investigate its physicochemical, antimicrobial, and anticancer properties

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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(±)-Ibuprofen A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC₅₀ = 4.85 µM).

Sigma-Aldrich

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(±)-Ibuprofen

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I0020000

Ibuprofen

Caffeine powder, ReagentPlus®

Sigma-Aldrich

C0750

Caffeine

Acetaminophen analytical standard

Sigma-Aldrich

A3035

Acetaminophen

Ibuprofen solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

I-009

Ibuprofen solution

Naproxen meets USP testing specifications

Sigma-Aldrich

N8280

Naproxen

Ibuprofen Arginate ≥98% (HPLC)

Sigma-Aldrich

SML1842

Ibuprofen Arginate

Diclofenac sodium salt

Sigma-Aldrich

D6899

Diclofenac sodium salt

Untangling the bioactive properties of therapeutic deep eutectic solvents based on natural terpenes
Silva E, et al.
Current research in medicine (2021)
The Effects of Ibuprofen, Naproxen and Diclofenac on cell Apoptosis, Cell Proliferation and Histology Changes in Human Cholangiocarcinoma Cell Lines
Leksomboon R, et al.
Asian Pacific Journal of Cancer Prevention (2022)
PharmGKB summary: ibuprofen pathways
Mazaleuskaya LL, et al.
Pharmacogenetics and Genomics (2015)
Vascular and pulmonary effects of ibuprofen on neonatal lung development
Chen X, et al.
Respiratory Research (2023)
Mateusz P Czub et al.
Journal of medicinal chemistry, 63(13), 6847-6862 (2020-05-30)
Every day, hundreds of millions of people worldwide take nonsteroidal anti-inflammatory drugs (NSAIDs), often in conjunction with multiple other medications. In the bloodstream, NSAIDs are mostly bound to serum albumin (SA). We report the crystal structures of equine serum albumin

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Discover Bioactive Small Molecules for Lipid Signaling Research

Chromatograms

suitable for GC

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