The gene IKKγ, also referred to as IKBKG (inhibitor of κ light polypeptide gene enhancer in B-cells, kinase γ) encodes the regulatory subunit of the inhibitor of κB kinase (IKK) complex, which also contains two catalytic subunits-IKK1/IKKα and IKK2/IKKβ. By phosphorylating IκB proteins, the IKK complex mediates the activation of NF (nuclear factor)-κB in response to a variety of stimuli. The gene is mapped to human chromosome Xq28.
synthetic peptide corresponding to amino acids 400-416 of human IKKγ.
The gene IKKγ, also referred to as NEMO (NF-κB essential modulator) interacts with IKKβ and is required for the activation of the IKK complex. Upon stimulation, IKK phosphorylates, ubiquitinates and degrades the NF-κB inhibitors, IκBα and IκBβ. This releases NF-κB, which in turn, enters the nucleus and activates target genes involved in immune and inflammatory responses. Mutations in this gene have been associated with incontinentia pigmenti, anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID), and other immunodeficiencies.
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Solution in phosphate buffered saline containing 0.02% sodium azide.
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