I5273

Interleukin-5 human

recombinant, expressed in baculovirus infected Sf21 cells, ≥97% (SDS-PAGE), lyophilized powder, suitable for cell culture

• Synonym(s): IL-5
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00163946

Properties

• biological source: human
• Quality Segment: 200
• recombinant: expressed in baculovirus infected Sf21 cells
• assay: ≥97% (SDS-PAGE)
• form: lyophilized powder
• potency: 0.1-0.5 ng/mL ED₅₀
• mol wt: 32-34 kDa
• packaging: pkg of 5 μg
• concentration: 0.5-10 ng/mL
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• UniProt accession no.: P05113
• storage temp.: −20°C
• Gene Information: human ... IL5(3567)

Description

Biochem/physiol Actions

IL-5 (interleukin-5) is a maturation and differentiation factor for eosinophils. Thus, it is associated with allergy and related disorders.[1] IL-5 association with its receptor causes activation of MEK/ERK (mitogen activated protein kinase kinase/extracellular-regulated kinase), p38 MAPK (mitogen activated protein kinase) and JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathways.[2]

Interleukin-5 is a product of activated T lymphocytes and exhibits activity on eosinophils, B cells and thymocytes. Synonyms or biological activities attributed to IL-5 include: EDF (eosinophil differentiating factor), BCGF-II (B cell growth factor-II), TRF (T cell replacing factor), IgA-EF (IgA enhancing factor) and EO-CSF (eosinophil colony stimulating factor). Natural IL-5 is a 45-50 kDa dimeric glycoprotein, although glycosylation is not required for activity. Human and mouse IL-5 exhibit homology at the nucleotide and amino acid levels and show species cross-reactivity.

Physical form

Lypholized from 0.2 um filtered solution of PBS, pH 7.2 with 50 ug BSA.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)