I5385

Sigma-Aldrich

Monoclonal Anti-Human IgG1 (Fab specific) G1m(f) antibody produced in mouse

clone SG-16, ascites fluid

MDL number:
NACRES:
NA.46
Pricing and availability is not currently available.

Quality Level

biological source

mouse

antibody form

ascites fluid

antibody product type

secondary antibodies

clone

SG-16, monoclonal

contains

15 mM sodium azide

application(s)

indirect ELISA: 1:5,000

isotype

IgG1

conjugate

unconjugated

shipped in

dry ice

storage temp.

−20°C

Related Categories

General description

Monoclonal Anti-Human IgG1 (mouse IgG1isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Human IgGs are glycoprotein antibodies that contain two equivalent light chains and a pair of identical heavy chains. IgGs have four distinct isoforms, ranging from IgG1 to IgG4.

Immunogen

Purified human IgG

Application

Monoclonal anti-Human IgG1 may be used for the identification of human IgG1 subclass by means of various immunoassays. It can be used in direct hemagglutination (HA) and hemagglutination inhibition (HAI) assays, immunofluorometric assay (IFMA) and detection of cytoplasmic IgG. Monoclonal anti-human IgG1 has been used in enzyme linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Human IgGs regulate immunological responses to allergy and pathogenic infections. IgGs have also been implicated in complement fixation and autoimmune disorders This product clone recognizes the G1m(f) allotype and has been established as a useful human IgG1 specificity standard by the WHO/IUIS study.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Hazard Codes

Xn

Risk Statement

21/22

Safety Statement

36/37-60

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation
Yamazaki R, et al.
Experimental Hematology, 39(12), 1119-1123 (2011)
Allotype analysis to distinguish the origin of varicella-zoster virus immunoglobulin G after allogeneic stem cell transplantation
Yamazaki R, et al.
Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation, 19(7), 1013-1020 (2013)
Andreas Lossius et al.
Annals of clinical and translational neurology, 4(10), 756-761 (2017-10-20)
Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to multiple sclerosis (MS) and IgG levels in the cerebrospinal fluid (CSF). However, how these variants are implicated in disease mechanisms remains unknown. Here, we show that proliferating plasmablasts expressing...
Rie Yamazaki et al.
Experimental hematology, 39(12), 1119-1123 (2011-09-14)
Myelodysplastic syndrome (MDS) is known to be associated with functional abnormalities of B cells, including hypergammaglobulinemia and monoclonal gammopathy (MG). However, the pathogenesis of these immunological disorders has not been clarified. We report a patient who developed donor-derived MDS followed...
Papadea C. and Check IJ.
Critical Reviews in Clinical Laboratory Sciences, 27, 27-58 (1989)

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