I5771
Interleukin-6 Receptor Soluble Fragment human
recombinant, expressed in Sf21 cells, ≥97% (SDS-PAGE), lyophilized powder
Synonym(s):
IL-6 sR
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25 μG
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Product Name
Interleukin-6 Receptor Soluble Fragment human, recombinant, expressed in Sf21 cells, ≥97% (SDS-PAGE), lyophilized powder
recombinant
expressed in Sf21 cells
assay
≥97% (SDS-PAGE)
form
lyophilized powder
impurities
endotoxin, tested
storage temp.
−20°C
Quality Level
1 of 4
This Item | I4269 | 407653 | SCU0001 |
|---|---|---|---|
| recombinant expressed in Sf21 cells | recombinant expressed in E. coli | recombinant - | recombinant expressed in HEK 293 cells |
| assay ≥97% (SDS-PAGE) | assay ≥98% (SDS-PAGE) | assay ≥97% (SDS-PAGE) | assay ≥98% (SDS-PAGE) |
| form lyophilized powder | form lyophilized powder | form lyophilized | form lyophilized powder |
| impurities endotoxin, tested | impurities ≤1.000 EU/μg | impurities ≤1 EU/μg Endotoxin | impurities ≤0.1 EU/μg protein (LAL test) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −70°C | storage temp. −20°C |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
Application
Interleukin-6 Receptor soluble fragment elicits a 50% increase in IL-6 activity in cell based assay at a concentration (EC50) of 1-10 ng/ml.
Analysis Note
The receptor mediated activity of human IL-6 receptor soluble fragment is measured by its ability to increase the IL-6 inhibition of M1 cells.[1]
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Interleukin-6 is a pleotropic cytokine involved in hematopoiesis, inflammation and immune response. IL-6 is secreted by macrophages, dendritic cells and B cells, in response to TNF-α, PGDF and IL-1. The signaling by IL-6 is mediated by heterodimeric receptor, IL-6R, comprising of IL-6Rα (soluble factor) and gp130 (sometimes called IL-6Rβ). Gp130 is crucial component for downstream signal transduction. In response to IL-6, gp130 activates kinases of JAK family, STATs, MAPK and Ras proteins. [2][3][4] IL-6R-mediated signaling is essential for normal development of T and B cells [5] and has been implicated in many diseases such as rheumatoid arthritis, Crohn disease, sepsis, fever, systemic lupus erythematosus, osteoporosis and insulin resistance[3][6][7][8]
Interleukin-6 Receptor soluble fragment specifically binds and inhibits the activity of human IL-6 in free form or when bound to cell surface receptors.
Interleukin-6 Receptor soluble fragment specifically binds and inhibits the activity of human IL-6 in free form or when bound to cell surface receptors.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Interleukin-6-type cytokines.
P B Sehgal et al.
Annals of the New York Academy of Sciences, 762, 1-14 (1995-07-21)
David S Hong et al.
Cancer, 110(9), 1911-1928 (2007-09-13)
Interleukin-6 (IL-6) plays a major role in the response to injury or infection and is involved in the immune response, inflammation, and hematopoiesis. Its deregulation impacts numerous disease states, including many types of cancer. Consequently, modulating IL-6 may be an
T van der Poll et al.
Infectious disease clinics of North America, 13(2), 413-426 (1999-05-26)
Clinical trials with anti-inflammatory agents in patients with sepsis are based on the assumption that excessive proinflammatory activity of the cytokine network negatively influences the outcome of severe bacterial infections. The failure of these trials to show clinical benefit, in
T Gustot et al.
Gut, 54(4), 488-495 (2005-03-09)
Soluble cytokine receptors (sCRs) modulate the in vivo activity of cytokines. Deficient sCR production could participate in the pathogenesis and course of Crohn's disease (CD). The aim of the study was to examine the profile of sCRs in CD patients
T Saito et al.
Journal of immunology (Baltimore, Md. : 1950), 147(1), 168-173 (1991-07-01)
Starting with a previously isolated cDNA clone encoding murine IL-6R, a stable transformed Chinese hamster ovary cell line constitutively expressing soluble murine IL-6R (smIL-6R) has been established. The smIL-6R was purified to homogeneity by sequential filtration and chromatography of culture
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