I6284

Sigma-Aldrich

Anti-Human IgE (ε-chain specific) antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(s):
Anti-Human Ige, Anti Human Ige, Anti-Human IgE - Anti-Human IgE (ε-chain specific) antibody produced in goat
MDL number:
NACRES:
NA.46

Quality Level

biological source

goat

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

application(s)

Ouchterlony double diffusion: suitable

conjugate

unconjugated

storage temp.

2-8°C

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General description

IgE is a class of immunoglobulins that is produced only in mammals. IgE is secreted by mast cells in response to allergens and is important in immunity against parasites. It also is the most important factor in the pathophysiology of anaphylaxis or type I hypersensitivity. The antibody preparation is specific for human IgE when tested against purified human IgA, IgG, IgM, Bence Jones κ, and Bence Jones λ proteins. Identity and purity of the antibody is established by immunoelectrophoresis.

Immunogen

Purified human IgE (myeloma)

Application

Anti-Human IgE (epsilon-chain specific) antibody may be used as a control in various immunoassays.

Physical form

Lyophilized from 0.01 M sodium phosphate, 0.015 M sodium chloride, pH 7.2.

Reconstitution

Reconstitute with 0.135 M sodium chloride to achieve a 1 mg/mL solution of antibody.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Stephen J Galli et al.
Nature medicine, 18(5), 693-704 (2012-05-09)
Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to think of them in other contexts. However, a large body of evidence...
Shiteng Duan et al.
The Journal of clinical investigation, 129(3), 1387-1401 (2019-01-16)
Allergen immunotherapy for patients with allergies begins with weekly escalating doses of allergen under medical supervision to monitor and treat IgE mast cell-mediated anaphylaxis. There is currently no treatment to safely desensitize mast cells to enable robust allergen immunotherapy with...
Jie Zhao et al.
mAbs, 11(5), 837-847 (2019-04-06)
Asthma is characterized by airway hyperresponsiveness and inflammation, as well as underlying structural changes to the airways. Interleukin-4 (IL-4) is a key T-helper type 2 (Th2) cytokine that plays important roles in the pathogenesis of atopic and eosinophilic asthma. We...
Gökhan Cildir et al.
Immunity, 51(5), 949-965 (2019-10-28)
Mast cells (MCs) are versatile immune cells capable of rapidly responding to a diverse range of extracellular cues. Here, we mapped the genomic and transcriptomic changes in human MCs upon diverse stimuli. Our analyses revealed broad H3K4me3 domains and enhancers...
Articles
Antibody-based serology tests are useful in identifying subjects with an adaptive immune response to the SARS-CoV-2 virus. Anti-human immunoglobulin antibodies allow for quick and simple, yet reliable assays with easy readouts and can also be adapted for high-throughput screening.
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