The product is soluble at 50mg/mL of Ethanol. Stock solutions are stable for up to 6 months at -20°C.
I7378
Indomethacin
98.5-100.5% (in accordance with EP), powder or crystals, COX inhibitor
Synonym(s):
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
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$85.80
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$169.00
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$748.00
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About This Item
Empirical Formula (Hill Notation):
C19H16ClNO4
CAS Number:
Molecular Weight:
357.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
200-186-5
MDL number:
Beilstein/REAXYS Number:
497341
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Product Name
Indomethacin, 98.5-100.5%, meets EP testing specifications
InChI key
CGIGDMFJXJATDK-UHFFFAOYSA-N
InChI
1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
SMILES string
COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3
biological source
synthetic
assay
98.5-100.5% (in accordance with EP)
98.5-100.5%
Quality Level
Gene Information
human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224)
rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)
agency
meets EP testing specifications
form
powder or crystals
loss
≤0.5% loss on drying
mp
158-162 °C
mode of action
enzyme | inhibits
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Related Categories
1 of 4
This Item | 405268 | I8280 | I0200000 |
|---|---|---|---|
| assay 98.5-100.5% (in accordance with EP) | assay ≥98% (by assay) | assay 98.0-102.0% | assay - |
| form powder or crystals | form powder | form powder | form - |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level - |
| biological source synthetic | biological source - | biological source - | biological source - |
| loss ≤0.5% loss on drying | loss - | loss - | loss - |
| mp 158-162 °C | mp - | mp - | mp - |
Application
Biochem/physiol Actions
Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome.[4] Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis.[5]
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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The New England Journal of Medicine, 343(10), 674-681 (2000)
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