MilliporeSigma
All Photos(1)

I7908

Sigma-Aldrich

Interleukin-2 human

recombinant, expressed in Pichia pastoris, suitable for cell culture

Sign Into View Organizational & Contract Pricing

Select a Size

Synonym(s):
IL-2, Interleukin-2, T-cell growth factor
MDL number:
NACRES:
NA.75

biological source

human

Quality Level

recombinant

expressed in Pichia pastoris

Assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

mol wt

predicted mol wt ~15 kDa

packaging

pkg of 10KU

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... IL2(3558)

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
I4161I2644SRP3085
Sigma-Aldrich

Sigma-Aldrich

I7908

Interleukin-2 human

Sigma-Aldrich

Sigma-Aldrich

I2644

Interleukin-2 human

Sigma-Aldrich

Sigma-Aldrich

SRP3085

Interleukin-2, human

recombinant

expressed in Pichia pastoris

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

assay

≥97% (SDS-PAGE)

assay

-

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized

mol wt

predicted mol wt ~15 kDa

mol wt

17.2 kDa

mol wt

15.5 kDa

mol wt

15.5 kDa

packaging

pkg of 10KU

packaging

pkg of 5X20 μg, pkg of 20 μg

packaging

pkg of 5X10 μg, pkg of 10 μg

packaging

pkg of 50 μg

Application

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Biochem/physiol Actions

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Analysis Note

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 6

1 of 6

D-Mannitol BioXtra, ≥98% (HPLC)

Sigma-Aldrich

M9546

D-Mannitol

Interleukin-4 human IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

I4269

Interleukin-4 human

Sigma-Aldrich

Sigma-Aldrich

SRP3071

IL-10 human

Sigma-Aldrich

Sigma-Aldrich

I1645

Interleukin-8 human

Racha Bahri et al.
Cancers, 14(12) (2022-06-25)
The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL), a peripheral T lymphoma of poor prognosis in at least 90% of cases. The role of EBV in this pathology is unknown. Using next-generation sequencing, we sequenced the
Nader Bayda et al.
Cancers, 13(4) (2021-02-10)
The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL) in more than 80% of cases. Few studies have focused on this association and it is not clear now what role the virus plays in this pathology. We
Meera V Singh et al.
Journal of leukocyte biology, 109(4), 807-820 (2020-07-15)
In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2-microglobulin, and IL-1β and release them upon activation. Previous studies indicate that activated platelets form transient complexes with monocytes, especially in HIV infected individuals
The IL-2 receptor complex: its structure, function, and target genes
Minami, Y, et al.
Annual Review of Immunology, 11(1) (1993)
TNFR1 and TNFR2 expression and induction on human Treg cells from type 1 diabetic subjects
Heinrich M, et al.
Antibodies, 4(1), 34-47 (2015)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service