I8010

Sigma-Aldrich

Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in rabbit

whole antiserum

MDL number:

biological source

rabbit

Quality Level

antibody form

whole antiserum

antibody product type

secondary antibodies

clone

polyclonal

contains

15 mM sodium azide

application(s)

immunoelectrophoresis: suitable

conjugate

unconjugated

shipped in

dry ice

storage temp.

−20°C

Related Categories

General description

Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. IgG is usually found as a monomer. IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. About 70 percent of the total immunoglobulin consists of IgG. Immunoglobulin M (IgM ) is a high molecular weight protein that has five or six subunits. It is the first immunoglobulin produced by neonates.

Application

Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in rabbit has been used in enzyme-linked immunosorbent assay (ELISA) and sandwich ELISA.
Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in rabbit was used in sandwich ELISA as a standard.

Biochem/physiol Actions

Immunoglobulin M (IgM) acts as an antigen specific part of the B cell antigen receptor on the surface of B lymphocytes that are not stimulated, in its monomeric form. Polymeric IgM molecules also serve as important activators of the classical complement cascade. IgM is essential in agglutination and cytolytic reactions. Immunoglobulin G (IgG) participates in hypersensitivity type II and type III.
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections. IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. IgM antibodies are present as pentamers in the serum and are produced in response to antigens.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Molecular Genetics of Immunoglobulin, 17, 575-586 (1987)
The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: a xenotransplant model for huPBSC-initiated hematopoiesis
Goan SR, et al.
Blood, 86(1), 89-100 (1995)
The Immunoglobulins: Structure and Function, 1-26 (1998)
MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID. beige mouse model of infection.
Bridges CG, et al.
Antimicrobial Agents and Chemotherapy, 40(5), 1072-1077 (1996)
C G Bridges et al.
Antimicrobial agents and chemotherapy, 40(5), 1072-1077 (1996-05-01)
The novel acyclonucleotide derivative of guanine, 9-[2-methylidene-3-(phosphonomethoxy)propyl] guanine (MDL 74,968), had antiviral activity comparable to those of 9-(2-phosphonomethoxyethyl) adenine (PMEA) and 2',3'-dideoxyinosine against laboratory strains of both human immunodeficiency virus (HIV) types 1 and 2 cultured in MT-4 cells and...

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