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I8021

Sigma-Aldrich

L-N6-(1-Iminoethyl)lysine dihydrochloride

Synonym(s):

L-Lysine ω-acetamidine dihydrochloride, L-NIL dihydrochloride

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$136.00

About This Item

Empirical Formula (Hill Notation):
C8H17N3O2 · 2 HCl
CAS Number:
159190-45-1
Molecular Weight:
260.16
MDL number:
MFCD00270890
UNSPSC Code:
12352209
PubChem Substance ID:
24278827
NACRES:
NA.77

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biological source

synthetic (organic)

assay

≥97% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O

InChI

1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1

InChI key

OQIBCXRAFAHXMM-KLXURFKVSA-N

Gene Information

human ... NOS2(4843)

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L-N6-(1-Iminoethyl)lysine dihydrochloride

I8021

L-N6-(1-Iminoethyl)lysine dihydrochloride

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D-Val-Leu-Lys 4-nitroanilide dihydrochloride plasmin substrate

V0882

D-Val-Leu-Lys 4-nitroanilide dihydrochloride

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (TLC)

assay

≥98% (TLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

water: 50 mg/mL, clear, colorless

solubility

H2O: 15 mg/mL, clear

solubility

H2O: 50 mg/mL

solubility

water: 50 mg/mL, clear, colorless to yellow

biological source

synthetic (organic)

biological source

-

biological source

synthetic

biological source

-

Gene Information

human ... NOS2(4843)

Gene Information

-

Gene Information

-

Gene Information

-

Application

L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:
  • to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine[1]
  • to study its effects on leptin-induced inflammation in hepatocytes[2]
  • to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)[3]

Biochem/physiol Actions

Selective inhibitor of inducible nitric oxide synthase (iNOS).

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN6804
MKCM4357
MKCK8543
MKCJ8964
MKCD9670

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