Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

I8898

Ivermectin

α7 neuronal nicotinic acetylcholine receptor modulator, powder

Synonym(s):

22,23-Dihydroavermectin B1, MK-933

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice
250 mg

Available to ship onApril 08, 2026fromMILWAUKEE

$41.00
1 g

Available to ship onApril 08, 2026fromMILWAUKEE

$121.00

About This Item

CAS Number:
70288-86-7
UNSPSC Code:
12352200
PubChem Substance ID:
24278497
NACRES:
NA.77
MDL number:
MFCD00869511
Form:
powder
Quality level:
100

$41.00

Available to ship onApril 08, 2026Details

​
Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Ivermectin,

form

powder

Quality Level

100

solubility

MEK: 50 mg/mL

antibiotic activity spectrum

parasites

application(s)

agriculture
environmental

mode of action

cell membrane | interferes

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

SMILES string

[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC

InChI

1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

InChI key

AZSNMRSAGSSBNP-XPNPUAGNSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669)

General description

Ivermectin is a macro-cyclic lactone, derived from avermectin.[1] It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.[1]

Application

Ivermectin has been used:
  • in Caenorhabditis elegans fecundity assay
  • in larval development test
  • to measure in vivo topical acaricide activity of compounds in rats
  • to assess its acute and chronic effects to zebrafish
  • in percutaneous drug injection method to treat cystic echinococcosis
  • in liquid chromatography with fluorescence detection method

Biochem/physiol Actions

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Primarily ivermectin B1a.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
PHR1380I80000101354309
Ivermectin

Sigma-Aldrich

I8898

Ivermectin

Ivermectin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1380

Ivermectin

Ivermectin European Pharmacopoeia (EP) Reference Standard

I8000010

Ivermectin

Ivermectin United States Pharmacopeia (USP) Reference Standard

USP

1354309

Ivermectin

form

powder

form

-

form

-

form

-

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

MEK: 50 mg/mL

solubility

-

solubility

-

solubility

-

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

originator

-

originator

-

originator

-

mode of action

cell membrane | interferes

mode of action

-

mode of action

-

mode of action

-

Still not finding the right product?

Explore all of our products under Ivermectin

signalword

Danger

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCZ6135
MKCX8161
MKCV0451
MKCM8215
MKCM4277

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems
Stowe SD, et al.
Drug and Chemical Toxicology, 35(3), 310-315 (2012)
Ivermectin used in percutaneous drug injection method for the treatment of liver hydatid disease in sheep
Hokelek M, et al.
Gastroenterology, 122(4), 957-962 (2002)
R J Martin et al.
International journal for parasitology, 28(6), 849-862 (1998-07-23)
Two of three major types of anthelminitic, the avermectins and the nicotinic agonists, exert their therapeutic effect by an action on ligand-gated membrane ion-channels of nematodes. The avermectins, such as ivermectin, open glutamategated chloride channels which have so far been
View All Related Papers

Global Trade Item Number

SKUGTIN
I8898-250MG04061835374755
I8898-1G04061835374748

Questions

1–6 of 6 Questions  

  1. Is product I8898, Ivermectin the analytical standard grade level? if not, what level is it?

    1 answer

    1. This product is considered a research grade with an assigned quality level of 100. Other Ivermectin products available are primary or secondary pharmaceutical reference standards. Please see the link below to review additional information regarding product quality levels:
      https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/m-clarity-program

      Please see the following link to review alternative Ivermectin standard product options:
      https://www.sigmaaldrich.com/search/ivermectin-standard?focus=products&page=1&perpage=30&sort=relevance&term=ivermectin%20standard&type=product

      Helpful?

  2. What is the composition of the submoieties B1A and B1B in Product No. I8898, Ivermectin?

    1 answer

    1. Unfortunately we do not test each lot to determine the composition.  In the past, lots have been ~95% B1A and ~5% B1B; however there will be lot-to-lot variation.

      Helpful?

  3. What is the solution stability of Ivermectin (Product No. I8898)?

    1 answer

    1. Stock solutions of Ivermectin in DMSO at a concentration of 10 mM have been found to be stable for 2 weeks at -20°C, according to Shan, Q., et al., in Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel.  J. Biol. Chem., 276(16), 12556-12564 (2001).

      Helpful?

  4. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  5. What is the molecular weight of Product No. I8898, Ivermectin?

    1 answer

    1. This product is a mixture of two submoieties B1A, MW 891.1 and B1B, MW 877.1. It is typically predominantly B1A, so you may use a molecular weight of 890 in your calculations.

      Helpful?

  6. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

Reviews

No rating value

Active Filters