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I8907

Sigma-Aldrich

Interferon β from rat

≥95%, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

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Synonym(s):
IFN-β
MDL number:
NACRES:
NA.32

biological source

rat

Quality Level

recombinant

expressed in CHO cells

Assay

≥95%

form

lyophilized powder

mol wt

~20 kDa

packaging

pkg of 1 vial

concentration

≥100000 units/mL

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

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Sigma-Aldrich

Sigma-Aldrich

I8907

Interferon β from rat

Interferon-γ from rat ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

I3275

Interferon-γ from rat

Sigma-Aldrich

Sigma-Aldrich

I4401

Interferon-αA/D human

recombinant

expressed in CHO cells

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥95%

assay

≥97% (SDS-PAGE)

assay

≥95%

assay

≥95%

form

lyophilized powder

form

lyophilized powder

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

~20 kDa

mol wt

15.5 kDa

mol wt

~20 kDa

mol wt

19 kDa

packaging

pkg of 1 vial

packaging

pkg of 0.1 mg

packaging

pkg of 1 vial

packaging

pkg of 100K units

Biochem/physiol Actions

Interferon β belongs to the type 1 interferon family pf proteins. It is also needed for the inhibition of tumor cell growth via cell death, S-phase increase and mediating differentiation. It is also important for bone homeostasis.
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.

Physical form

Lyophilized from phosphate buffered saline (PBS) containing 125 mM trehalose.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV). The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. Since there is no international rat interferon β standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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25G
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R B Pepinsky et al.
The Journal of pharmacology and experimental therapeutics, 297(3), 1059-1066 (2001-05-18)
Interferon therapies suffer from a relatively short half-life of the products in circulation. To address this issue we investigated the effects of polyethylene glycol modification (PEGylation) on the pharmacokinetic properties of human interferon (IFN)-beta-1a. PEGylation with a linear 20-kDa PEG
C Ren et al.
Gene therapy, 15(21), 1446-1453 (2008-07-04)
Cell-based therapy for cancer is a promising new field. Among cell types that can be used for this purpose, mesenchymal stem cells (MSCs) appear to hold great advantage for reasons including easier propagation in culture, possible genetic modification to express
Junqiang Ye et al.
PloS one, 6(6), e20681-e20681 (2011-06-17)
The production of type I interferons (IFNs) in response to viral infections is critical for antiviral immunity. However, IFN production is transient, and continued expression can lead to inflammatory or autoimmune diseases. Thus, understanding the mechanisms underlying the negative regulation
J Adriaansen et al.
Human gene therapy, 17(10), 985-996 (2006-09-21)
Interferon (IFN)-beta has significant immunomodulatory properties and has received much interest as a potentially therapeutic agent for rheumatoid arthritis (RA). Systemic IFN-beta treatment of patients with RA was not effective, probably because of pharmacokinetic issues. Therefore, we studied the effect
S Rubinstein et al.
Journal of virology, 37(2), 755-758 (1981-02-01)
A convenient assay for interferons based on reduction of cytopathic effect was developed. The number of manipulations and the lengths of the various incubation steps were reduced to a minimum. The assay is simple to perform and can be completed

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