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I9385

Sigma-Aldrich

Anti-Human IgM (μ-chain specific) antibody produced in rabbit

whole antiserum

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2 ML
$78.00

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2 ML
$78.00

About This Item

MDL number:
MFCD00162459
UNSPSC Code:
12352203
NACRES:
NA.46

$78.00

List Price$156.00Save 50%
Web-Only Promotion

In StockDetails

Request a Bulk Order

biological source

rabbit

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

secondary antibodies

clone

polyclonal

contains

15 mM sodium azide

technique(s)

indirect ELISA: 1:20,000

shipped in

dry ice

Storage temp.

−20°C

target post-translational modification

unmodified

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This Item
A6907I8885A3150
Anti-Human IgM (μ-chain specific) antibody produced in rabbit whole antiserum

I9385

Anti-Human IgM (μ-chain specific) antibody produced in rabbit

Anti-Human IgM (μ-chain specific)−Peroxidase antibody produced in goat affinity isolated antibody, buffered aqueous solution

A6907

Anti-Human IgM (μ-chain specific)−Peroxidase antibody produced in goat

Anti-Human IgG (Fc specific) antibody produced in goat whole antiserum

I8885

Anti-Human IgG (Fc specific) antibody produced in goat

Anti-Human IgG (γ-chain specific)−Alkaline Phosphatase antibody produced in goat affinity isolated antibody, buffered aqueous glycerol solution

A3150

Anti-Human IgG (γ-chain specific)−Alkaline Phosphatase antibody produced in goat

antibody form

whole antiserum

antibody form

affinity isolated antibody

antibody form

whole antiserum

antibody form

affinity isolated antibody

technique(s)

indirect ELISA: 1:20,000

technique(s)

direct ELISA: 1:10,000

technique(s)

indirect ELISA: 1:50,000, quantitative precipitin assay: 4.0-7.0 mg/mL

technique(s)

direct ELISA: 1:7,000-1:21,000

conjugate

unconjugated

conjugate

peroxidase conjugate

conjugate

unconjugated

conjugate

alkaline phosphatase conjugate

biological source

rabbit

biological source

goat

biological source

goat

biological source

goat

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

General description

IgM is a pentameric immunoglobulin, with each monomer having a light and heavy chain. The two types of IgM comprise natural and adaptive.

Application

Anti-Human IgM (μ-chain specific) antibody produced in rabbit has been used in enzyme linked immunosorbent assay.

Biochem/physiol Actions

IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
IgM serves as prime antibody in providing defense. It activates complement C1q. It is regarded as a marker for identifying tumor-associated antigens. Hyper-IgM syndrome is implicated with high IgM levels accompanied by low IgA, IgG and IgE levels.

Preparation Note

treated to remove lipoproteins

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
077M4866V
21170418
077M4866V
032M4799V
098K4831

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Evaluation of a patient with hyper-IgM syndrome
Uygungil B, et al.
The Journal of Allergy and Clinical Immunology, 129(6), 1692-1692 (2012)
The human IgM pentamer is a mushroom-shaped molecule with a flexural bias
Czajkowsky DM and Shao Z
Proceedings of the National Academy of Sciences of the USA, 106(35), 14960-14965 (2009)
Natural and adaptive IgM antibodies in the recognition of tumor-associated antigens of breast cancer
Diaz-Zaragoza M, et al.
Oncology Reports, 34(3), 1106-1114 (2015)
Antibodies reacting with human immunoglobulin in sera from autoimmune thyroid disease patients as a risk factor for false positive results in IgA assessment
Haroun M and El-Masry MH
Central European Journal of Immunology, 33, 208-212 (2008)
E J Wiersma et al.
Journal of immunology (Baltimore, Md. : 1950), 160(12), 5979-5989 (1998-06-24)
Previous studies have discerned two forms of polymeric mouse IgM: moderately cytolytic (complement-activating) pentamer, which contains J chain, and highly cytolytic hexamer, which lacks J chain. To investigate the relationships among polymeric structure, J chain content, and cytolytic activity, we

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