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I9532

Icilin

≥97% (HPLC), CMR1 receptor agonist, solid

Synonym(s):

1-(2-Hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetra­hydro­pyrimidin-2-one, AG-3-5

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10 mg

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$199.00
50 mg
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$853.00

About This Item

Empirical Formula (Hill Notation):
C16H13N3O4
CAS Number:
36945-98-9
Molecular Weight:
311.29
UNSPSC Code:
12352200
PubChem Substance ID:
24277906
NACRES:
NA.77
MDL number:
MFCD01689072
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
100

$199.00

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Product Name

Icilin, ≥97% (HPLC), solid

Quality Level

100

assay

≥97% (HPLC)

form

solid

color

yellow

solubility

DMSO: 15 mg/mL

SMILES string

Oc1ccccc1N2CC=C(NC2=O)c3cccc(c3)[N+]([O-])=O

InChI

1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)

InChI key

RCEFMOGVOYEGJN-UHFFFAOYSA-N

General description

Icilin is a synthetic cooling agent and modulates human transient receptor potential cation channel (TRPA1). Icilin inhibits transient receptor potential cation channel subfamily M member 8 (TRPM8) and modulates calcium release. Icilin also suppresses transient receptor potential vanilloid subtype 3 (TRPV3).

Application

Icilin has been used as cooling agent in anterior ventromedial preoptic area (VMPO) neurons.

Biochem/physiol Actions

Icilin is a potent agonist at the CMR1 cold- and menthol-sensitive receptor.

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This Item
I3766658403553008
Icilin ≥97% (HPLC), solid

Sigma-Aldrich

I9532

Icilin

Isoliquiritigenin powder

Sigma-Aldrich

I3766

Isoliquiritigenin

AG 538 A potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC50 = 400 nM).

Sigma-Aldrich

658403

AG 538

Raf1 Kinase Inhibitor I The Raf1 Kinase Inhibitor I, also referenced under CAS 220904-83-6, controls the biological activity of Raf1 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

553008

Raf1 Kinase Inhibitor I

assay

≥97% (HPLC)

assay

-

assay

≥95% (HPLC)

assay

≥97% (HPLC)

form

solid

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

solubility

DMSO: 15 mg/mL

solubility

H2O: <0.1 mg/mL, methanol: 10 mg/mL, DMSO: 20 mg/mL

solubility

DMSO: 5 mg/mL

solubility

DMSO: 200 mg/mL

color

yellow

color

yellow to orange

color

dark orange to brown

color

dark orange

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000519790
0000519790
0000420678
0000420678
0000191673

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Warm-sensitive neurons that control body temperature
Tan CL, et al.
Cell, 167(1), 47-59 (2016)
Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3
Sherkheli MA, et al.
TheScientificWorldJournal, 2012(6), 859-869 (2012)
Inhibition of TRPM8 by icilin distinct from desensitization induced by menthol and menthol derivatives
Kuhn FJP, et al.
The Journal of Biological Chemistry, 284(7), 4102-4111 (2009)
View All Related Papers

Global Trade Item Number

SKUGTIN
I9532-10MG04061833865705
I9532-50MG04061832556826

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