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JN0004

Sigma-Aldrich

Tolmetin sodium dihydrate

≥98% (HPLC)

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Synonym(s):
Tolmetin sodium salt dihydrate, 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid sodium salt dihydrate, Sodium 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate dihydrate, 1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium salt dihydrate
Linear Formula:
C15H14NO3Na · 2H2O
CAS Number:
Molecular Weight:
315.30
MDL number:

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

room temp

SMILES string

[Na+].[H]O[H].[H]O[H].Cc1ccc(cc1)C(=O)c2ccc(CC([O-])=O)n2C

InChI

1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1

InChI key

QQILXENAYPUNEA-UHFFFAOYSA-M

Gene Information

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This Item
1670502M3935S7198
Tolmetin sodium United States Pharmacopeia (USP) Reference Standard

USP

1670502

Tolmetin sodium

form

powder

form

-

form

powder

form

solid

color

white to beige

color

-

color

light yellow to dark yellow

color

white to off-white

solubility

H2O: 2 mg/mL, clear

solubility

-

solubility

DMSO: 5 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

storage temp.

room temp

storage temp.

-

storage temp.

room temp

storage temp.

room temp

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Gene Information

human ... PTGS2(5743)

Gene Information

-

Biochem/physiol Actions

Tolmetin sodium is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthetase in vitro and reduces plasma levels of prostaglandin E. Tolmetin sodium exhibits anti-inflammatory, analgesic and antipyretic activity Its precise mechanism of is unknown. Tolmetin is used to treat rheumatoid arthritis, osteoarthrosis, pain, and ankylosing spondylitis.

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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J Davies et al.
Current medical research and opinion, 7(2), 115-120 (1980-01-01)
A double-blind crossover study was carried out in 21 patients with osteoarthrosis of the hip to compare the effectiveness and tolerance of 1200 mg tolmetin sodium daily with 75 mg indomethacin daily. Each drug was given in 3 equally divided
F J Persico et al.
The Journal of pharmacology and experimental therapeutics, 247(3), 889-896 (1988-12-01)
The glycine amide of tolmetin sodium (TGA) functions as a prodrug and was demonstrated to be more potent than the parent compound as an inhibitor of developing and established adjuvant arthritis in the female Lewis rat. In contrast, the glycine
Afaf A Ramadan et al.
Journal of pharmaceutical investigation, 48(6), 673-683 (2019-01-01)
The objective of the present study was to develop rectal mucoadhesive hydrogels loaded with Tolmetin Sodium, a non-steroidal anti-inflammatory drug, for prolonged duration of action and increased bioavailability. Fourteen formulae were prepared with different types and concentrations of polymers as

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