N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24
Mellergaard M, et al.
The Journal of Biological Chemistry, 289(29), 20078-20091 (2014)
Christopher N Scanlan et al.
Journal of molecular biology, 372(1), 16-22 (2007-07-17)
The HIV envelope has evolved a dense array of immunologically "self" carbohydrates that efficiently protect the virus from antibody recognition. Nonetheless, one broadly neutralising antibody, IgG1 2G12, has been shown to recognise a cluster of oligomannose glycans on the HIV-1...
Mohsan Saeed et al.
The Journal of biological chemistry, 286(43), 37264-37273 (2011-09-01)
Viral infections frequently cause endoplasmic reticulum (ER) stress in host cells leading to stimulation of the ER-associated degradation (ERAD) pathway, which subsequently targets unassembled glycoproteins for ubiquitylation and proteasomal degradation. However, the role of the ERAD pathway in the viral...
Qun Zhou et al.
Biotechnology and bioengineering, 99(3), 652-665 (2007-08-08)
Glycosylation in the Fc region of antibodies has been shown to play an important role in antibody function. In the current study, glycosylation of human monoclonal antibodies was metabolically modulated using a potent alpha-mannosidase I inhibitor, kifunensine, resulting in the...
A D Elbein et al.
The Journal of biological chemistry, 265(26), 15599-15605 (1990-09-15)
Kifunensine, produced by the actinomycete Kitasatosporia kifunense 9482, is an alkaloid that corresponds to a cyclic oxamide derivative of 1-amino mannojirimycin. This compound was reported to be a weak inhibitor of jack bean alpha-mannosidase (IC50 of 1.2 x 10(-4) M)...