Phosphatidylinositol-4-phosphate-5-kinase, type 1γ (PIP5K1C) belongs to the type I phosphatidylinositol-4-phosphate-5-kinases. This protein is expressed at high levels in the brain and is concentrated at synapses. The PIP5K1C gene is located on the human chromosome at 19p13.3.
Anti-PIP5K1C (N-terminal) specifically recognizes human, rat, and mouse PIP5K1C.
Anti-PIP5K1C (N-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Phosphatidylinositol-4-phosphate-5-kinase, type 1γ (PIP5K1C) is involved in phosphorylating phosphatidylinositol-4-phosphate (PtdInsP) to generate phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2). PIP5K1C has been shown to bind to the 4.1/ezrin/radixin/moesin (FERM) domain of talin, which contains also the binding sites of β-integrin, actin, and PtdIns(4,5)P2. PIP5K1C is recruited to the membrane by talin at neuronal synapses may be required to generate the PtdIns(4,5)P2 pool involved in clathrin coating and actin dynamics during vesicle recycling. Mutations in the PIP5K1C gene is associated with lethal congenital contracture syndrome type 3 (LCCS3), which is an intense form of arthrogryposis.
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
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