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K3768

Sigma-Aldrich

PYK2 (360-690), active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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Synonym(s):
CADTK, CAKB, FADK2, FAK2, PKB, PTK, PTK2B, RAFTK
NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

product line

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

216-292 nmol/min·mg

mol wt

~39 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PTK2B(2185)

General description

PYK2 (proline-rich tyrosine kinase 2, also known as FAK2/RAFTK) belongs to the focal adhesion PTK (protein tyrosine kinase) family. It is activated by signals that increases intracellular calcium concentration and also by stress signals. PYK2 is present in the endothelium, central nervous system, and hematopoietic lineages.

Biochem/physiol Actions

In osteoclasts, PYK2 (proline-rich tyrosine kinase 2) might be a crucial mediator of integrin αvβ3 signaling events that affects osteoclast physiology as well as pathology. It has a tumor-promoting role in multiple myeloma.

Physical form

Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Wen-Cheng Xiong et al.
Frontiers in bioscience : a journal and virtual library, 8, d1219-d1226 (2003-09-06)
Integrin alpha(v)beta3 plays a pivotal role in osteoclastic bone resoprtion by mediating both osteoclast attachments on bone matrix and cytoskeleton reorganization. The focal adhesion kinase (FAK) family kinases including FAK and proline-rich tyrosine kinase 2 (PYK2) are major tyrosine kinases
H Avraham et al.
Cellular signalling, 12(3), 123-133 (2000-03-08)
Intracellular signal transduction following extracellular ligation by a wide variety of surface molecules involves the activation and tyrosine phosphorylation of protein tyrosine kinases (PTKs). Tyrosine phosphorylation, controlled by the coordinated actions of protein tyrosine phosphatases (PTPs) and tyrosine kinases, is
Yu Zhang et al.
Blood, 124(17), 2675-2686 (2014-09-14)
Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family that has been recently linked to tumor development. However, its role in modulating multiple myeloma (MM) biology and disease progression remains unexplored. We first demonstrated that

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