K3888

Kenpaullone

≥98%

• Synonym(s): 9-Bromo-7,12-dihydro-indolo­[3,2-d]­[1]benzazepin-6(5H)-one, NSC 664704
• Empirical Formula (Hill Notation): C₁₆H₁₁BrN₂O
• CAS Number: 142273-20-9
• Molecular Weight: 327.18
• MDL number: MFCD02683595
• PubChem Substance ID: 24278507

Properties

• Quality Level: 100
• Assay: ≥98%
• form: solid
• color: yellow
• solubility: DMSO: 18 mg/mL, clear, yellow
• storage temp.: 2-8°C
• SMILES string: Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
• InChI: 1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
• InChI key: QQUXFYAWXPMDOE-UHFFFAOYSA-N
• Gene Information: human ... CDC2(983) ; mouse ... Gsk3b(56637) ; rat ... Gsk3b(84027)

Description

Application

Kenpaullone has been used:

• as a glycogen synthase kinase 3 (GSK3)/ cyclin-dependent kinase (CDK) inhibitor to study its effects on human neural progenitor cell lines
• as an inhibitor of Krupple-like factor 4 (KLF4) in Gs-coupled designer GPCR (Gs DREADD= GsD) Agouti-related peptide (GsD-AgRP) mice
• as a GSK3/CDK inhibitor to study its effects on the sea urchin embryo development

Biochem/physiol Actions

Kenpaullone is also an inhibitor of glycogen synthase kinase 3β (GSK3β). It also inhibits cyclin-dependent kinase 1 (CDK1/cyclin B), CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25, majorly by competitive inhibition of adenosine triphosphate (ATP) binding.

Features and Benefits

This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Store under argon

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves