All Photos(1)
K4394
PKF118-310
≥98% (HPLC)
All Photos(1)
Synonym(s):
1,6-Dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, Xanthothricin, Toxoflavin
Empirical Formula (Hill Notation):
C7H7N5O2
CAS Number:
Molecular Weight:
193.16
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN1N=CN=C(C1=N2)C(N(C)C2=O)=O
InChI
1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
InChI key
SLGRAIAQIAUZAQ-UHFFFAOYSA-N
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.
Signal Word
Danger
Hazard Statements
Precautionary Statements
RIDADR
UN 2811 6.1 / PGIII
WGK Germany
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificate of Analysis
Certificate of Origin
More documents
Jinwoo Kim et al.
Molecular microbiology, 54(4), 921-934 (2004-11-04)
Burkholderia glumae BGR1 produces a broad-host range phytotoxin, called toxoflavin, which is a key pathogenicity factor in rice grain rot and wilt in many field crops. Our molecular and genetic analyses of toxoflavin-deficient mutants demonstrated that gene clusters for toxoflavin...
Boknam Jung et al.
Nature communications, 9(1), 31-31 (2018-01-04)
Bacterial-fungal interactions are widely found in distinct environments and contribute to ecosystem processes. Previous studies of these interactions have mostly been performed in soil, and only limited studies of aerial plant tissues have been conducted. Here we show that a...
Ji-Eun Choi et al.
PloS one, 13(1), e0183893-e0183893 (2018-01-03)
Toxoflavin, a 7-azapteridine phytotoxin produced by the bacterial pathogens such as Burkholderia glumae and Burkholderia gladioli, has been known as one of the key virulence factors in crop diseases. Because the toxoflavin had an antibacterial activity, a metagenomic E. coli...
Phyllis S Y Chong et al.
Oncogene, 38(9), 1508-1519 (2018-10-12)
Aberrant activation of Wnt/β-catenin signaling pathway is essential for the development of AML; however, the mechanistic basis for this dysregulation is unclear. PRL-3 is an oncogenic phosphatase implicated in the development of LSCs. Here, we identified Leo1 as a direct...
K A Buckle et al.
The Journal of applied bacteriology, 68(6), 571-576 (1990-06-01)
Tempe bongkrek was prepared from partially defatted coconut by fermentation with the mould Rhizopus oligosporus. The addition of 2% sodium chloride decreased but did not inhibit formation of bongkrek acid by Pseudomonas cocovenenans strain ITB in either coconut culture medium...
Related Content
n proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during the synthesis (S) phase, which is followed by a second gap phase (G2) during which growth and preparation for cell division occurs. Together, these three stages comprise the interphase phase of the cell cycle. Interphase is followed by the mitotic (M) phase.
Read MoreOur team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical ServiceSupport
Customer SupportContact UsFAQSafety Data Sheets (SDS)Certificates (COA/COO)Quality & RegulatoryCalculators & AppsWebinarsSocial Media
MilliporeSigma
Research. Development. Production.
We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.
© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.
Reproduction of any materials from the site is strictly forbidden without permission.