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MilliporeSigma

K4394

Sigma-Aldrich

PKF118-310

≥98% (HPLC)

Synonym(s):

1,6-Dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, Toxoflavin, Xanthothricin

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5 MG
$157.70
25 MG
$464.80

About This Item

Empirical Formula (Hill Notation):
C7H7N5O2
CAS Number:
Molecular Weight:
193.16
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

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$157.70

List Price$166.00Save 5%
Web-Only Promotion

In StockDetails


Request a Bulk Order
Technical Service
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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

H2O: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN1N=CN=C(C1=N2)C(N(C)C2=O)=O

InChI

1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3

InChI key

SLGRAIAQIAUZAQ-UHFFFAOYSA-N

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1 of 4

This Item
SML1142PZ0111SML1382
PKF118-310 ≥98% (HPLC)

K4394

PKF118-310

PD-407824 ≥98% (HPLC)

PZ0111

PD-407824

XMD8-92 ≥98% (HPLC)

SML1382

XMD8-92

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: >10 mg/mL

solubility

DMSO: 25 mg/mL, clear

color

white to light brown

color

white to beige

color

yellow to orange

color

white to beige

Biochem/physiol Actions

PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.
PKF118-310 is a Tcf4/b-catenin antagonist.

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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