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K4894

Sigma-Aldrich

Kolliphor® P 188

solid

Synonym(s):
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol® F68, Poloxamer 188
CAS Number:
MDL number:
NACRES:
NA.75

form

solid

Quality Level

mol wt

8.400 g/mol

pH

5.0-7.5(2.5% solution)

application(s)

sample preservation

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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General description

Kolliphor® P 188 is a non-ionic amphiphilic copolymer, which has a central chain of hydrophobic polyoxypropylene and a hydrophilic polyoxyethylene at the ends.

Application

Kolliphor® P 188 has been used as a component of cell-dissociation/minimal essential media (MEM) to sort tumor cells using EpCAM antibody-conjugated magnetic beads.
Kolliphor® P 188 has been used as a supplement in F17 medium for the culture of HEK293-6E cells. It has also been used as a component of flow cytometry (FACS) buffer as a non-ionic detergent that protects cells from hydrodynamic damage.

Packaging

500 g in poly bottle

Biochem/physiol Actions

Kolliphor® P 188 exhibits cytoprotective, hemorheological, anti-inflammatory, antithrombotic activities. It maintains the stability of membrane barrier function. P188 lowers surface tension and hydrophobic-based cellular adherence. It also inhibits lipid peroxidation stimulated by Fe2+ and H2O2.

Legal Information

Kolliphor is a registered trademark of BASF
Lutrol is a registered trademark of BASF SE

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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