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MilliporeSigma

K4894

Sigma-Aldrich

Poloxamer 188

solid

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68

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500 G
$142.00

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500 G
$142.00

About This Item

CAS Number:
MDL number:
UNSPSC Code:
12161902
NACRES:
NA.75

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$142.00


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agency

USP/NF
meets USP testing specifications

Quality Level

form

solid

mol wt

8.400 g/mol

pH

5.0-7.5(2.5% solution)

application(s)

sample preservation

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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1 of 4

This Item
1.37112P489416758
form

solid

form

solid

form

solid, waxy solid

form

powder

application(s)

sample preservation

application(s)

liquid formulation
ophthalmics
parenterals
pharma/biopharma processes
pharmaceutical
semi-solid formulation
solid formulation
solubility enhancement

application(s)

-

application(s)

-

Quality Level

300

Quality Level

500

Quality Level

100

Quality Level

100

mol wt

8.400 g/mol

mol wt

-

mol wt

-

mol wt

-

agency

USP/NF

agency

NF, Ph. Eur.

agency

-

agency

-

pH

5.0-7.5(2.5% solution)

pH

5-7.5 (20 °C, 10 g/L in H2O)

pH

5.0-7.5

pH

5.0-7.5

General description

Poloxamer 188 is a non-ionic amphiphilic copolymer, which has a central chain of hydrophobic polyoxypropylene and a hydrophilic polyoxyethylene at the ends.[1]

Application

Poloxamer 188 has been used as a component of cell-dissociation/minimal essential media (MEM) to sort tumor cells using EpCAM antibody-conjugated magnetic beads.[2]
Poloxamer 188 has been used as a supplement in F17 medium for the culture of HEK293-6E cells.[3] It has also been used as a component of flow cytometry (FACS) buffer [4] as a non-ionic detergent that protects cells from hydrodynamic damage.

Biochem/physiol Actions

Poloxamer 188 exhibits cytoprotective, hemorheological, anti-inflammatory, antithrombotic activities. It maintains the stability of membrane barrier function. P188 lowers surface tension and hydrophobic-based cellular adherence. It also inhibits lipid peroxidation stimulated by Fe2+ and H2O2.[1]

Legal Information

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1


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Questions

  1. How long can a 0,001% solution be stored at 4°C?

    1 answer
    1. The stability of a 0.001% solution at 4°C has not been tested. A solution of 100 mg/ml in water is stable for 1 year at -80°C and for 1 month at -20°C. It is recommended to aliquot the stock solutions to avoid repeated freeze-thaw cycles.

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