The stability of a 0.001% solution at 4°C has not been tested. A solution of 100 mg/ml in water is stable for 1 year at -80°C and for 1 month at -20°C. It is recommended to aliquot the stock solutions to avoid repeated freeze-thaw cycles.
K4894
Poloxamer 188
solid
Synonym(s):
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68
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| Size/SKU | Availability | Price |
|---|---|---|
500 g | Check Cart for Availability | $152.00 |
About This Item
$152.00
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Quality Segment
agency
USP/NF, meets USP testing specifications
form
solid
mol wt
8.400 g/mol
pH
5.0-7.5(2.5% solution)
application(s)
sample preservation
SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
General description
Poloxamer 188 is a non-ionic amphiphilic copolymer, which has a central chain of hydrophobic polyoxypropylene and a hydrophilic polyoxyethylene at the ends.[1]
Application
Poloxamer 188 has been used as a supplement in F17 medium for the culture of HEK293-6E cells. It has also been used as a component of flow cytometry (FACS) buffer as a non-ionic detergent that protects cells from hydrodynamic damage.
Poloxamer 188 has been used as a component of cell-dissociation/minimal essential media (MEM) to sort tumor cells using EpCAM antibody-conjugated magnetic beads.[2]
Biochem/physiol Actions
Poloxamer 188 exhibits cytoprotective, hemorheological, anti-inflammatory, antithrombotic activities. It maintains the stability of membrane barrier function. P188 lowers surface tension and hydrophobic-based cellular adherence. It also inhibits lipid peroxidation stimulated by Fe2+ and H2O2.[1]
Legal Information
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This Item | |||
|---|---|---|---|
| description solid | description EMPROVE® EXPERT, (stabilized with 70ppm BHT), Ph. Eur., ChP, JPE, NF | description solid, suitable for cell culture | description European Pharmacopoeia (EP) Reference Standard |
| form solid | form solid | form solid, waxy solid | form - |
| application(s) sample preservation | application(s) liquid formulation | application(s) - | application(s) pharmaceutical (small molecule) |
| Quality Level 300 | Quality Level 500 | Quality Level 100 | Quality Level - |
| mol wt 8.400 g/mol | mol wt - | mol wt - | mol wt - |
| pH 5.0-7.5(2.5% solution) | pH 5-7.5 (20 °C, 10 g/L in H2O) | pH 5.0-7.5 | pH - |
| agency USP/NF | agency ChP, JPE, NF, Ph. Eur. | agency - | agency - |
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Storage Class
11 - Combustible Solids
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How long can a 0,001% solution be stored at 4°C?
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