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L0881

Sigma-Aldrich

Lectin from Arachis hypogaea (peanut)

lyophilized powder, Affinity-purified

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Synonym(s):
PNA, Peanut agglutinin
NACRES:
NA.32

form

lyophilized powder

Quality Level

potency

<0.1 μg per mL agglutination activity

quality

Affinity-purified

impurities

salt, free

storage temp.

−20°C

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This Item
L0770L6512L3382
potency

<0.1 μg per mL agglutination activity

potency

<20 μg per mL agglutination activity

potency

-

potency

<4 μg per mL agglutination activity

impurities

salt, free

impurities

salt, free

impurities

salt, free

impurities

salt, free

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

quality

Affinity-purified

quality

-

quality

-

quality

-

General description

Lectin from Arachis hypogaea (peanut) is a homotetrameric protein of 110 kDa.

Application

Lectin from Arachis hypogaea (peanut) has been used:
  • to detect Thomson-Friedenreich antigen
  • as a component in PBS to study its effects on cell viability
  • to study its ability to block the binding site

Biochem/physiol Actions

Lectin from Arachis hypogaea (peanut) possess specificity towards β -D-Gal(1-3)-D-galNAc residue of Thomson − Friedenreich antigen. It is the most widely used diagnostic and prognostic marker for many squamous cell carcinomas.
PNA does not agglutinate normal human erythrocytes, but strongly agglutinates neuraminidase treated erythrocytes. PNA has potent anti-T activity similar to the anti-T antibody in human sera. The lectin can be used to distinguish between human lymphocyte subsets.

Analysis Note

Agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of neuraminidase treated human blood group O erythrocytes after 1 hr incubation at 25 °C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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