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L135

Sigma-Aldrich

L-741,626

≥98% (HPLC)

Synonym(s):

(±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole

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10 MG
$158.65
50 MG
$491.40

About This Item

Empirical Formula (Hill Notation):
C20H21ClN2O
CAS Number:
Molecular Weight:
340.85
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

$158.65

List Price$167.00
Web-Only Promotion

In StockDetails


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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥20 mg/mL
ethanol: 24 mg/mL
H2O: insoluble

storage temp.

room temp

SMILES string

OC1(CCN(CC1)Cc2c[nH]c3ccccc23)c4ccc(Cl)cc4

InChI

1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2

InChI key

LLBLNMUONVVVPG-UHFFFAOYSA-N

Gene Information

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This Item
SML0369PZ0342SML1804
L-741,626 ≥98% (HPLC)

L135

L-741,626

AM4113 ≥98% (HPLC)

SML1804

AM4113

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: ≥20 mg/mL, H2O: insoluble, ethanol: 24 mg/mL

solubility

DMSO: 10 mg/mL (clear solution)

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

white to light brown

color

white to brown

Application

L-741,626 has been used as selective dopamine (D2) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells.[1] It has also been used as a D2 receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.[2]

Biochem/physiol Actions

L-741,626 is a selective dopamine (D2) receptor antagonist.[3]

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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