Low-density lipoprotein receptor-related protein-6 (LRP6) is expressed primarily in the central nervous system. This protein is made up of three subdomains in the extracellular domain, such as epidermal growth factor (EGF)-like domain, YWTD-type β-propeller domain, and low-density lipoprotein receptor (LDLR) type A (LA) domain. The LRP6 gene is located on the human chromosome at 12p13.2.
Anti-LRP6 (C-terminal region) specifically recognizes human LRP6.
Anti-LRP6 (C-terminal region) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Low-density lipoprotein receptor-related protein-6 (LRP6) is essential for proper brain development. The LRP6 protein forms a Wnt-Frizzled (Fz)-LRP6 complex that recruits axin to the plasma membrane resulting in the inhibition of βcatenin phosphorylation and degradation, and activation of T-cell factor (TCF)/lymphoid enhancer-binding factor-1 (LEF-1)-dependent transcription. Deletion of the LRP6 gene results in severe brain abnormalities. LRP6 also plays a central role in human disease. Mutations in the LRP6 gene are associated with coronary heart disease and osteoporosis.
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
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