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MilliporeSigma

L2262

Lipopolysaccharides from Salmonella enterica serotype typhimurium

purified by gel-filtration chromatography

Synonym(s):

LPS

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5 MG

$308.00

25 MG

$1,510.00

$308.00

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.25
MDL number:
MFCD00164404

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biological source

Salmonella enterica (Serotype typhimurium)

form

lyophilized powder

purified by

gel-filtration chromatography

impurities

<1% Protein

color

white to faint yellow

solubility

water: 0.90-1.10 mg/mL, hazy to turbid, colorless to faintly yellow

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

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Lipopolysaccharides from Salmonella enterica serotype typhimurium purified by gel-filtration chromatography

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Lipopolysaccharides from Salmonella enterica serotype typhimurium BioXtra, suitable for cell culture, &#947;-irradiated

Sigma-Aldrich

L6143

Lipopolysaccharides from Salmonella enterica serotype typhimurium

biological source

Salmonella enterica (Serotype typhimurium)

biological source

Salmonella enterica (Serotype typhimurium)

biological source

Salmonella enterica (Serotype typhimurium)

biological source

Salmonella enterica (serotype typhimurium)

solubility

water: 0.90-1.10 mg/mL, hazy to turbid, colorless to faintly yellow

solubility

water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow

solubility

water: 4.90-5.10 mg/mL, slightly hazy to turbid, colorless to faintly yellow

solubility

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

color

white to faint yellow

color

white to faint yellow

color

white to faint yellow

color

-

General description

This product is extracted from Salmonella typhimurium and purified by gel filtration. The source strain is ATCC 7823.

Application

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Biochem/physiol Actions

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

Preparation Note

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

Other Notes

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000536179
0000536179
0000507319
0000507319
0000490035

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Barbara Chirullo et al.
Frontiers in microbiology, 6, 985-985 (2015-10-07)
Salmonella Typhimurium (S. Typhimurium) is responsible for foodborne zoonotic infections that, in humans, induce self-limiting gastroenteritis. The aim of this study was to evaluate whether the wild-type strain S. Typhimurium (STM14028) is able to exploit inflammation fostering an active infection.
Rossella Paolillo et al.
International immunopharmacology, 9(11), 1265-1271 (2009-08-04)
Probiotics, defined as live microbial food supplements which improve the health of the host, have obtained increasing medical importance. In the intestine they may prevent the overgrowth of pathogenic bacteria, increase the resistance of the gut to invasion by pathogens
Alun C Kirby et al.
Infection and immunity, 72(11), 6390-6400 (2004-10-27)
The location and functional properties of antigen-specific memory T-cell populations in lymphoid and nonlymphoid compartments following DNA immunization or infection with Salmonella were investigated. Epitope-specific CD8+ -T-cell expansion and retention during the memory phase were analyzed for DNA-immunized mice by
Rui F D S Mesquita et al.
Molecular and cellular biology, 34(4), 574-594 (2013-12-04)
The pathways which regulate resolution of inflammation and contribute to positive remodeling of the myocardium following injury are poorly understood. Here we show that protein kinase C epsilon (PKCε) cooperates with the phosphatase calcineurin (CN) to potentiate induction of cardioprotective
Jia Lin Ren et al.
Scientific reports, 8(1), 429-429 (2018-01-13)
Inflammation is in a wide spectrum of retinal diseases, causing irreversible blindness and visual impairment. We have previously demonstrated that Green Tea Extract (GTE) is a potent anti-inflammatory agent for anterior uveitis. Here we investigated the anti-inflammatory effect of GTE
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Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Related Content

Lipopolysaccharides

Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.

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