L2880

Sigma-Aldrich

Lipopolysaccharides from Escherichia coli O55:B5

purified by phenol extraction

Synonym(s):
LPS
EC Number:
MDL number:
NACRES:
NA.25

Quality Level

biological source

Escherichia coli (O55:B5)

form

lyophilized powder

purified by

phenol extraction

impurities

<3% Protein (Lowry)

shipped in

ambient

storage temp.

2-8°C

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General description

Lipopolysaccharides (LPSs) consist of a lipid A moiety linked to an antigenic O-polysaccharide.

Application

Lipopolysaccharide from Escherichia coli O55:B5 has been used:
  • to stimulate hepatocytes and non-parenchymal cells
  • to stimulate the spleen and study the expression of the Malitaf gene in the fish blunt snout bream
  • as part of the concanavalin A (ConA) and D-galactosamine/lipopolysaccharide (D-GalN/LPS) model of fulminant hepatitis to study the effect of the natural compound hesperetin
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Packaging

10 mg in poly bottle
25, 100, 500 mg in glass bottle

Biochem/physiol Actions

Lipid A plays a role in the biological properties attributed to endotoxic LPS. LPS is a highly immunogenic antigen which has the ability to enhance immune responses.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

hazcat

Acute Tox. 2 Oral

storage_class_code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Identification and Characterization of Lipopolysaccharide Induced TNFa Factor from Blunt Snout Bream, Megalobrama amblycephala
Yina LV
International Journal of Molecular Sciences, 18(2), 233-233 (2017)
A liver microphysiological system of tumor cell dormancy and inflammatory
responsiveness is affected by scaffold properties
Clark AM
Cancer Discovery null
The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro
Xueting Bai
British Journal of Pharmacology, 174 (2017)
K Amor et al.
Infection and immunity, 68(3), 1116-1124 (2000-02-26)
In the lipopolysaccharides of Escherichia coli there are five distinct core oligosaccharide (core OS) structures, designated K-12 and R1 to R4. The objective of this work was to determine the prevalences of these core OS types within the species. Unique...
Novel adjuvants & delivery vehicles for vaccines development: a road ahead.
Mohan T
The Indian Journal of Medical Research, 138(5), 779-795 (2013)
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