Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals. Unfortunately, a β-Lactoglobulin from bovine milk that is suitable for food applications is not offered.
L3908
β-Lactoglobulin from bovine milk
≥90% (PAGE), lyophilized powder
Synonym(s):
βLg, BLG, Bos d 5, beta-lactoglobulin
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250 MG
$79.50
1 G
$243.00
5 G
$898.00
About This Item
Form:
lyophilized powder
Assay:
≥90% (PAGE)
Biological source:
bovine milk
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biological source
bovine milk
assay
≥90% (PAGE)
form
lyophilized powder
technique(s)
ELISA: suitable
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
bovine ... LGB(280838)
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This Item | |||
|---|---|---|---|
| biological source bovine milk | biological source bovine milk | biological source bovine milk | biological source bovine milk |
| technique(s) ELISA: suitable | technique(s) titration: suitable | technique(s) HPLC: suitable | technique(s) activity assay: suitable, electrophoresis: suitable, immunocytochemistry: suitable |
| assay ≥90% (PAGE) | assay ≥85% (PAGE) | assay ≥90% (PAGE) | assay 87-94% protein basis |
| form lyophilized powder | form lyophilized powder | form powder | form powder |
| Gene Information bovine ... LGB(280838) | Gene Information bovine ... LGB(280838) | Gene Information bovine ... LGB(280838) | Gene Information bovine ... CSN1S1(282208), CSN1S2(282209), CSN2(281099), CSN3(281728) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
General description
Milk from dairy cows contains the protein β-lactoglobulin (BLG). It naturally occurs in a number of genetic variants, and the most prevalent bovine variants are BLG A and BLG B.[1]
Application
β-Lactoglobulin was used in a cytologic assay for diagnosis of food hypersensitivity in patients with irritable bowel syndrome.[2]
Biochem/physiol Actions
A member of the lipocalin family, βLg is a small protein of 162 amino acids with a molecular mass of ∼18,400 Da. It features an eight-stranded β-barrel (strands A-H) succeeded by a three-turn a-helix and a final β-strand (strand I) that forms part of the dimerization interface.[3]
Preparation Note
Chromatographically purified
Analysis Note
May not contain folate binding protein; not recommended for folate analysis.
Other Notes
Contains β-lactoglobulins A and B which can be isolated chromatographically.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Sirpa Jylhä et al.
Journal of immunological methods, 350(1-2), 63-70 (2009-08-04)
Cow's milk allergy (CMA) is a common food allergy, especially among infants and young children. Approximately 85% of milk-allergic children outgrow their allergy by the age of three but the remaining 15% remain allergic. Bovine beta-lactoglobulin (BLG) is one of
Tilman Barz et al.
Journal of chromatography. A, 1217(26), 4267-4277 (2010-05-07)
In this work, parameters of the steric mass-formalism SMA are optimally ascertained for a reliable determination of the adsorption isotherms of beta-lactoglobulin A and B under non-isocratic conditions. For this purpose, static batch experiments are used in contrast to the
Lena Wartosch et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(12), 4056-4068 (2009-08-08)
Mutations in either ClC-7, a late endosomal/lysosomal member of the CLC family of chloride channels and transporters, or in its beta-subunit Ostm1 cause osteopetrosis and lysosomal storage disease in mice and humans. The severe phenotype of mice globally deleted for
Jonathan Vaneyck et al.
The Journal of biological chemistry, 296, 100358-100358 (2021-02-05)
The aggregation of the protein α-synuclein (aSyn) into amyloid fibrils in the human brain is associated with the development of several neurodegenerative diseases, including Parkinson's disease. The previously observed prion-like spreading of aSyn aggregation throughout the brain and the finding
Junzhen Zhong et al.
Food chemistry, 278, 491-496 (2018-12-26)
Previous work indicated that conformational changes of β-lactoglobulin (β-LG) induced by dynamic high pressure microfluidization (DHPM) was related to the increase of antigenicity. In this study, β-LG glycated with 1-kestose and combined with DHPM decreased the antigenicity of β-LG. The
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Sehr geehrte Damen und Herren, ist das Beta-Lactoglobin EG-Nummer: 232-928-9 MDL-Nummer: MFCD00130635 welches bei ihnen erhältlich ist für die Lebensmittel Industrie zugelassen? Unser Unternehmen braucht es für eine Getränke Herstellung.
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What is the preferred buffer to dilute the product in? Or is it deionized water with or without protease inhibitors? (Application: SDS-PAGE gels and western blot)
1 answer-
This product is not tested for solubility. Various sources suggest that this material may be reconstituted in water or aqueous buffers at 5 mg/ml. This information has not been validated.
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does this product have other components such as sucrose, trehalose or salts?
1 answer-
This product is prepared from skimmed milk. Lactoglobulins are precipitated and further purified chromatographically. The final dialysis process depletes most residual salts. The minimum purity of this product is 90%. While sugars such as trehalose and sucrose would not be expected, the impurities of this product have not been identified.
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How is the solubility of the product in water?
1 answer-
This product is not tested for solubility. Various sources suggest that this material may be reconstituted in water or aqueous buffers at 5 mg/ml. This information has not been validated.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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What is the molecular weight of Product L3908, β-Lactoglobulin from bovine milk?
1 answer-
Product L3908, β-Lactoglobulin from bovine milk, exists as a dimer of two peptides. Peptide A = 18,367, B = 18,281; the monomer is approximately 36,600.
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