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L4040

Sigma-Aldrich

Lactoferrin human

recombinant, expressed in rice, Partially iron saturated, ≥90% (SDS-PAGE)

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Synonym(s):
Growth-inhibiting protein 12, Lactotransferrin, Talalactoferrin
MDL number:
MFCD00164307
NACRES:
NA.61

biological source

human

recombinant

expressed in rice

Assay

≥70% protein basis (Bradford)
≥90% (SDS-PAGE)

form

powder

technique(s)

microbiological culture: suitable

solubility

H2O: soluble 10 mg/mL

UniProt accession no.

P02788

storage temp.

2-8°C

Gene Information

human ... LTF(4057)

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This Item
L377061327L1294
Lactoferrin human recombinant, expressed in rice, Partially iron saturated, ≥90% (SDS-PAGE)

Sigma-Aldrich

L4040

Lactoferrin human

Lactoferrin from human milk Iron saturated, ≥85% (SDS-PAGE)

Sigma-Aldrich

L3770

Lactoferrin from human milk

Sigma-Aldrich

Sigma-Aldrich

61327

Lactoferrin from human milk

Lactoferrin human recombinant, expressed in rice, Iron saturated, ≥90% (SDS-PAGE)

Sigma-Aldrich

L1294

Lactoferrin human

recombinant

expressed in rice

recombinant

-

recombinant

-

recombinant

expressed in rice

assay

≥70% protein basis (Bradford), ≥90% (SDS-PAGE)

assay

≥85% (SDS-PAGE)

assay

≥85% (GE)

assay

≥90% (SDS-PAGE), ≥90% (biuret)

form

powder

form

powder

form

solid

form

powder

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

technique(s)

-

technique(s)

microbiological culture: suitable

solubility

H2O: soluble 10 mg/mL

solubility

phosphate buffer: 10 mg/mL at 25 °C (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4)

solubility

0.05 M NaCl: 1 mg/mL, clear to faintly turbid, faintly red to brown

solubility

-

Application

Lactoferrin was used to grow Streptococcus mutans in an iron-limiting medium. It was used to test if lactoferrin impedes epithelial cell adhesion in vitro. It was also used to test the diagnostic value of blood cytokine concentrations in acute pneumonia.

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Thuy Nguyen Thi Dao et al.
Journal of extracellular vesicles, 11(2), e12195-e12195 (2022-02-22)
Cancer cell-derived extracellular vesicles (EVs) are promising biomarkers for cancer diagnosis and prognosis. However, the lack of rapid and sensitive isolation techniques to obtain EVs from clinical samples at a sufficiently high yield limits their practicability. Chimeric nanocomposites of lactoferrin
Chuang Guo et al.
Food & function, 11(8), 7183-7196 (2020-08-07)
Lactoferrin (Lf), an iron-binding glycoprotein, has been shown to possess antioxidant and anti-inflammatory properties and exert modulatory effects on lipid homeostasis and non-alcoholic fatty liver disease (NAFLD), but our understanding of its regulatory mechanisms is limited and inconsistent. We used
Qingsheng Kong et al.
Molecular and cellular biochemistry, 406(1-2), 293-299 (2015-05-20)
The metalloprotease lethal factor (LF) from Bacillus anthracis plays a vital role in anthrax toxin action, and thus becomes a target for anti-anthrax therapy. Following the guidelines based on existing metalloprotease inhibitors, we designed a 'first-generation' LF inhibitor R9LF-1. This
Shelton W Wright et al.
PLoS neglected tropical diseases, 14(8), e0008495-e0008495 (2020-08-09)
Melioidosis is an often-severe tropical infection caused by Burkholderia pseudomallei (Bp) with high associated morbidity and mortality. Burkholderia thailandensis (Bt) is a closely related surrogate that does not require BSL-3 conditions for study. Lactoferrin is an iron-binding glycoprotein that can
P Kragsbjerg et al.
Thorax, 50(12), 1253-1257 (1995-12-01)
The role of cytokines in the pathogenesis of pneumonia is still poorly understood. In a previous study the diagnostic value of measuring blood concentrations of interleukin 6 and interferon gamma was established. In the present study the value of blood
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