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L4920

Sigma-Aldrich

Luotonin E

≥98%

Linear Formula:
C19H13N3O2
CAS Number:
Molecular Weight:
315.33
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

assay

≥98%

form

solid

solubility

chloroform/methanol (4:1): 4 mg/mL, clear to slightly hazy, colorless to yellow

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TOP1(7150)

General description

Luotonin E is a heteroaromatic pyrroloquinazolinoquinoline alkaloid that, along with Luotonin A and B, was originally isolated from the Chinese medicinal plant Paganum nigellastrum. Luotonin compounds have antitumor activity and demonstrate cytotoxicity and inhibitory activity against human topoisomerase. For use as a topoisomerase inhibitor, a starting concentration of 25 μM is suggested. It is suggested that a dose-response curve be performed to find the inhibitor concentration most suitable for the intended assay.

Packaging

10 mg in glass bottle
50 mg in poly bottle

Biochem/physiol Actions

Luotonin E exhibited strong cytotoxic effects specifically on human leukemia P-388 cells.

Reconstitution

Solubility is tested at 4 mg/mL in 4:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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