Skip to Content
MilliporeSigma

L5768

Lanosterol

≥93%, powder

Synonym(s):

3β-Hydroxy-8,24-lanostadiene, 8,24-Lanostadien-3β-ol

Sign In to View Organizational & Contract Pricing

Select a Size

1 MG

$140.00

5 MG

$490.00

$140.00


Available to ship TODAYDetails


Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):
C30H50O
CAS Number:
Molecular Weight:
426.72
EC Number:
MDL number:
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.77

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

≥93%

form

powder

color

white to off-white

storage temp.

−20°C

SMILES string

[H][C@@]1(CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC3)[C@H](C)CC\C=C(/C)C

InChI

1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1

InChI key

CAHGCLMLTWQZNJ-BQNIITSRSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 2

This Item
D6513
form

powder

form

powder

assay

≥93%

assay

≥84% (GC)

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

color

white to off-white

color

-

General description

Lanosterol, an amphipathic molecule, that is produced by lanosterol synthase (LSS). It is enriched in the lens.[1]

Application

Lanosterol has been used:
  • as a standard in HPLC for the quantification in testis samples[2]
  • in S-adenosyl-L-methionine:Δ24-sterol-C-methyltransferase (SMT) assay[3]
  • to treat wild-type cells growing in rich medium to know its effects on Sre1 protein[4]

Biochem/physiol Actions

Cholesterol precursor sterol.
Lanosterol serves as an endogenous selective modulator of macrophage immunity.[5]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast
Porter J R, et al.
The Journal of Biological Chemistry, 285(52), 41051-41061 (2010)
Joanna L Sharman et al.
Nucleic acids research, 41(Database issue), D1083-D1088 (2012-10-23)
The International Union of Basic and Clinical Pharmacology (IUPHAR) database, IUPHAR-DB (http://www.iuphar-db.org) is an open access, online database providing detailed, expert-driven annotation of the primary literature on human and rodent receptors and other drug targets, together with the substances that
Lanosterol modulates TLR4-mediated innate immune responses in macrophages
Araldi E, et al.
Testing, 19(13), 2743-2755 (2017)
Lanosterol reverses protein aggregation in cataracts
Zhao L, et al.
Nature, 523(7562), 607-607 (2015)
Marja-Riitta Taskinen et al.
Journal of clinical lipidology, 14(1), 77-87 (2020-01-10)
Monoclonal antibodies to proprotein convertase subtilisin/kexin type 9 (PCSK9) significantly lower the levels of low-density lipoprotein and very-low-density lipoproteins (VLDL), but their effect on postprandial lipoprotein metabolism in dyslipidemic subjects is unclear. This study aimed to investigate the effects of

Articles

Discover Bioactive Small Molecules for Lipid Signaling Research

Cholesterol biosynthesis starts in the hepatic endoplasmic reticulum with acetyl-CoA, yielding 3-hydroxy-3-methylglutaryl-CoA via HMG-CoA synthase.

Questions

1–2 of 2 Questions  
  1. How to prepare this product for cell experiments?

    1 answer
    1. The product has not been tested for use in cell culture, and its solubility has been tested at 100 mg/mL in chloroform.

      Helpful?

  2. How to prepare this product for cell experiments?

    1 answer
    1. This product is not tested for use in cell culture. The solubility is tested at 100 mg/mL in Chloroform. See the link below to a publication that may be helpful.
      https://www.sciencedirect.com/science/article/pii/S0167488919302253

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service