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Sodium L-lactate


L-Lactic acid sodium salt, (S)-2-Hydroxypropionic acid sodium salt, Sarcolactic acid sodium salt
Empirical Formula (Hill Notation):
CAS Number:
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Quality Level




163-165 °C (lit.)

storage temp.


SMILES string




InChI key


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Sodium L-lactate has been used:
  • as a medium supplement and cell fuel source for human mammary epithelial cell line(MCF10A) and dendritic cell culture
  • as a gluconeogenic substrate in hepatic glucose production assay in primary hepatocytes
  • in the glucose production medium for glucose production assay in human embryonic kidney (HEK293T) cells
  • as a standard for calibration in lactate assay in bone marrow-derived macrophages


5, 10, 50 g in glass bottle

Biochem/physiol Actions

L-lactate is produced from pyruvate by the enzyme lactate dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells.

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Lactate is always the end product of glycolysis
Rogatzki MJ, et al.
Frontiers in Neuroscience, 9, 22-22 (2015)
Neuronal and astroglial monocarboxylate transporters play key but distinct roles in hippocampus-dependent learning and memory formation.
Netzahualcoyotzi, et al.
Progress in Neurobiology, 194, 101888-101888 (2020)
Protein-bound NAD (P) H Lifetime is Sensitive to Multiple Fates of Glucose Carbon
Sharick JT, et al.
Scientific Reports, 8(1), 5456-5456 (2018)
Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function
Galan-Davila AK, et al.
The Journal of Biological Chemistry, jbc-RA118 (2018)
Dynamic acetylation of phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions
Latorre-Muro P, et al.
Molecular Cell, 71(5), 718-732 (2018)


Glutamine Metabolism is Dysregulated in Many Cancer Cells

Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.

Aerobic Glycolysis and the Warburg Effect

We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.

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